Zika virus is an icosahedral, enveloped, single-stranded RNA virus that come from the Flaviviridae family & genus Flavivirus.

It is transmitted in humans through a bite of Aedes aegypti & Aedes albopictus mosquito.

In February 2016, the Zika virus infection was declared by the World Health Organization (WHO) as an international health emergency.

Pregnant women infected by Zika virus may pass their infection to the developing fetus & may cause birth defects such as microcephaly, ventriculomegaly, intracranial calcifications, extra-axial fluid, polymicrogyria, decreased brain parenchymal volume, hypoplasia of the cerebellum, brainstem or dermis, delayed myelination, thinning or hypoplasia of the corpus callosum & cortical atrophy & malformation.



Principles of Therapy

Principles of Therapy

  • There is no specific treatment for Zika virus infection thus, supportive and symptomatic treatment are given
  • Infected patients should be protected from further exposure to mosquito especially during the first few days of illness in order to prevent the other mosquitoes from becoming infected and to reduce local transmission
  • Supportive care which include bed rest, increase fluid intake and use of analgesic (only when fever and pain are present) are advised
  • For patients with Guillain-Barre syndrome, optimal care including neurologic exam, vital signs and respiratory function monitoring should be done frequently


Antipyretics and Analgesics

  • Paracetamol is used for fever and pain relief
  • Avoid Aspirin and other salicylates since these may cause gastritis, bleeding and acidosis
  • Patients are also advised to avoid taking Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) until dengue has been ruled out in order to decrease the risk of hemorrhage
    • Pregnant women at ≥32 weeks age of gestation (AOG) are advised to avoid taking NSAIDs in order to minimize the risk of having premature closure of the ductus arteriosus
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Editor's Recommendations
Most Read Articles
Tristan Manalac, 13 Mar 2018
In patients with end-stage renal disease (ESRD), varicella appears to be associated with high mortality and morbidity, a recent Singapore study has shown. Researchers thus recommend vaccination in ESRD patients seronegative for varicella.
Roshini Claire Anthony, 09 Mar 2018

Individuals using opioid analgesics may be at an elevated risk of invasive pneumococcal disease, particularly those using long-acting, high-potency, immunosuppressive, or high-dose opioids, results of a nested case-control study show.

09 Mar 2018
Apart from being tolerable and feasible, pre- and post-transplantation hepatitis C virus (HCV) treatments prevent HCV infection in non–HCV-infected recipients (ie, HCV D+/R− transplantation) of kidneys, a recent open-label nonrandomized trial in a single centre has shown.
2 days ago
Use of antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.