Zika virus is an icosahedral, enveloped, single-stranded RNA virus that comes from the Flaviviridae family and genus Flavivirus.
It is transmitted in humans through a bite of Aedes aegypti and Aedes albopictus mosquito.
In February 2016, the Zika virus infection was declared by the World Health Organization (WHO) as an international health emergency.
Pregnant women infected by Zika virus may pass their infection to the developing fetus and may cause birth defects such as microcephaly, ventriculomegaly, intracranial calcifications, extra-axial fluid, polymicrogyria, decreased brain parenchymal volume, hypoplasia of the cerebellum, brainstem or dermis, delayed myelination, thinning or hypoplasia of the corpus callosum and cortical atrophy and malformation.
White matter (WM) integrity in HIV-infected children is compromised despite early antiretroviral therapy (ART) and viral load (VL) suppression, with damage persisting at 5 years of age and evidence of new damage present, a recent study has shown.