Vitiligo is an acquired, often familial, melanocytopenic disorder that produces focal depigmentation of the skin.
About half of the patients has onset of lesion before the age of 20.
It is a progressive disease wherein spontaneous repigmentation may occur within 6 months.
Precipitating factors include emotional stress, sunburn, chemical exposure, skin trauma, inflammation, irritation or rash that may precede the lesions by 2-3 months.
Lesions are white-colored macules or patches with well-defined borders and otherwise normal skin surface.

Vitiligo References

  1. Al-Khawajah MM. Photochemotherapy for vitiligo: seven years experience at a university hospital. Ann Saudi Med. 1997;17:175-178. PMID: 17377425
  2. American Academy of Dermatology Association. Practice management: guidelines of care for phototherapy and photochemotherapy. J Am Acad Dermatol. 1994;31:643-648. PMID: 8089291
  3. American Academy of Dermatology Association. Practice management: guidelines of care of vitiligo. J Am Acad Dermatol. 1996;35:620-626
  4. Halder RM, Young CM. New and emerging therapies for vitiligo. Dermatol Clin. 2000;18:79-89. PMID: 10626114
  5. Kovacs SO. Vitiligo. J Am Acad Dermatol. 1998;38:647-666. PMID: 9591808
  6. Grimes PE, Sorano T, Dytoc MT. Topical tacrolimus for repigmentation of vitiligo. J Am Acad Dermatol. 2002;47:789-791. PMID: 12399778
  7. Natta R, Smosak T, Wisuttida, et al. Narrowband ultraviolet B radiation therapy for recalcitrant vitiligo in Asians. J Am Acad Dermatol. 2003;49:473-476. PMID: 12963911
  8. Lepe V, Moncada B, Castanedo-Cazares JP, et al. A double- blind randomize trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Arch dermatol. 2003;139:581-585. PMID: 12756094
  9. Menchini G, Tsoureli-Nikita E, Hercogova J. Narrow-band UV- B microphototherapy: a new treatment for vitiligo. J Eur Acad Dermatol. 2003;17:171-177. PMID: 12705746
  10. Spencer JM, Nossa R, Ajmeria J. Treatment of vitiligo with the 308-nm excimer laser: a pilot study. J Am Dermatol. 2002;46:727-731. PMID: 12004315
  11. Habif TP. Light-related diseases and disorders of pigmentation. Clinical dermatology: a color guide to diagnosis and therapy. 3rd ed: Mosby; 1996
  12. Su R. Vitiligo. In: Lo KK, Chong LY, Tang YM. Handbook of dermatology & venereology: social hygiene handbook. 2nd ed. Western District, Hong Kong: Hygiene Service, Dept of Health; 1997
  13. MedWorm
  14. Health information. A service of the US National Library of Medicine and the National Institutes of Health. Drug information: Trioxsalen (systemic);Thomson Micromedex 2003. Medline Plus. Accessed 18 Jul 2003
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.