Vitiligo is an acquired, often familial, melanocytopenic disorder that produces focal depigmentation of the skin.
About half of the patients has onset of lesion before the age of 20.
It is a progressive disease wherein spontaneous repigmentation may occur within 6 months.
Precipitating factors include emotional stress, sunburn, chemical exposure, skin trauma, inflammation, irritation or rash that may precede the lesions by 2-3 months.
Lesions are white-colored macules or patches with well-defined borders and otherwise normal skin surface.
  1. Al-Khawajah MM. Photochemotherapy for vitiligo: seven years experience at a university hospital. Ann Saudi Med. 1997;17:175-178. PMID: 17377425
  2. American Academy of Dermatology Association. Practice management: guidelines of care for phototherapy and photochemotherapy. J Am Acad Dermatol. 1994;31:643-648. PMID: 8089291
  3. American Academy of Dermatology Association. Practice management: guidelines of care of vitiligo. J Am Acad Dermatol. 1996;35:620-626
  4. Halder RM, Young CM. New and emerging therapies for vitiligo. Dermatol Clin. 2000;18:79-89. PMID: 10626114
  5. Kovacs SO. Vitiligo. J Am Acad Dermatol. 1998;38:647-666. PMID: 9591808
  6. Grimes PE, Sorano T, Dytoc MT. Topical tacrolimus for repigmentation of vitiligo. J Am Acad Dermatol. 2002;47:789-791. PMID: 12399778
  7. Natta R, Smosak T, Wisuttida, et al. Narrowband ultraviolet B radiation therapy for recalcitrant vitiligo in Asians. J Am Acad Dermatol. 2003;49:473-476. PMID: 12963911
  8. Lepe V, Moncada B, Castanedo-Cazares JP, et al. A double- blind randomize trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Arch dermatol. 2003;139:581-585. PMID: 12756094
  9. Menchini G, Tsoureli-Nikita E, Hercogova J. Narrow-band UV- B microphototherapy: a new treatment for vitiligo. J Eur Acad Dermatol. 2003;17:171-177. PMID: 12705746
  10. Spencer JM, Nossa R, Ajmeria J. Treatment of vitiligo with the 308-nm excimer laser: a pilot study. J Am Dermatol. 2002;46:727-731. PMID: 12004315
  11. Habif TP. Light-related diseases and disorders of pigmentation. Clinical dermatology: a color guide to diagnosis and therapy. 3rd ed: Mosby; 1996
  12. Su R. Vitiligo. In: Lo KK, Chong LY, Tang YM. Handbook of dermatology & venereology: social hygiene handbook. 2nd ed. Western District, Hong Kong: Hygiene Service, Dept of Health; 1997
  13. MedWorm
  14. Health information. A service of the US National Library of Medicine and the National Institutes of Health. Drug information: Trioxsalen (systemic);Thomson Micromedex 2003. Medline Plus. Accessed 18 Jul 2003
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