Long-term therapy with testosterone undecanoate (TU) in hypogonadal men with type 2 diabetes (T2D) may improve glycaemic control and reverse disease progression, as well as induce significant weight loss, according to a study presented at EASD 2018.
The use of the lymphocyte-selective antiproliferative agent mycophenolate mofetil (MMF) in lower doses is as effective as the chemotherapy drug cyclophosphamide in improving kidney function and reducing proteinuria during induction therapy for proliferative lupus nephritis (LN), a Nepalese trial shows.
The selective xanthine oxidoreductase (XOR) inhibitor topiroxostat reduced the serum uric acid (SUA) level of patients with hyperuricaemia and early diabetic nephropathy (DN) with microalbuminuria, preventing the decline in estimated glomerular filtration rate (eGFR), according to the UPWARD* study.
The 24-hour ambulatory or clinic blood pressure (BP) levels in hypertensive patients with reasonably well-controlled hypertension do not appear to be influenced by whether BP-lowering medications are taken in the morning or evening, according to the results of the HARMONY* trial.
Host factors, such as tumour (size, complexity) and patient characteristics (comorbidities, advanced age, abnormal body mass index [BMI], chronic kidney disease [CKD], prior abdominal surgery), affect the outcomes of robotic partial nephrectomy (RPN), according to the results of a meta-analysis.
Corticosteroids may protect renal function and reduce proteinuria in patients with immunoglobulin A nephropathy (IgAN), a chronic glomerular disease that may gradually progress to end-stage renal disease (ESRD), according to a meta-analysis.
A 12-month treatment course with the combination of mirabegron plus solifenacin is safe and effective in patients with overactive bladder (OAB), reducing the number of incontinence episodes and micturition without unexpected toxicities, according to the results of the phase III SYNERGY II study.
The phosphodiesterase type 5 inhibitor tadalafil significantly improved the erectile function of patients receiving the 5-alpha reductase inhibitor (5-α RI) dutasteride for the management of bladder outlet obstruction, according to a Turkish study.
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.