Initial active treatment is associated with generally worse long-term self-reported quality of life (QoL) in men with localized prostate cancer compared with those without a diagnosis of the disease, according to a study. Furthermore, radical prostatectomy results in some adverse effects, particularly in relation to sexual outcomes.
Olaparib, a PARP* inhibitor used to treat ovarian and breast cancer, also extends overall survival (OS) of men with metastatic castration-resistant prostate cancer (mCRPC) harbouring at least one mutation in BRCA1, BRCA2, or ATM, according to final report of the PROfound** study presented at ESMO 2020.
Durvalumab with or without tremelimumab in the first-line setting does not improve overall survival (OS) over standard-of-care (SoC) chemotherapy in patients with unresectable, locally advanced or metastatic urothelial carcinoma, according to the phase III DANUBE trial.
Dilutional therapy with tolvaptan favourably alters cystine saturation in the urine and increases urine output in patients with cystinuria, as shown in a small study, suggesting the drug’s potential in reducing the recurrence of stones in this population.
Delays in radical prostatectomy due to the novel coronavirus disease (COVID-19) pandemic does not result in adverse pathology, upgrading, nodal metastasis, or use of postsurgery secondary treatments, according to a recent study.
Tobacco smoking exposure appears to result in lower neoadjuvant chemotherapy response rates as well as higher overall and cancer-specific mortality, according to a systematic review and meta-analysis. Smoking status is also associated with bladder cancer recurrence after radical cystectomy.
The placement of an absorbable perirectal hydrogel spacer (HS) led to prostate-rectum separation with less rectal irradiation, fewer rectal toxicities, and better bowel-related quality of life (QoL) in men undergoing radiotherapy (RT) for prostate cancer (PCa), a meta-analysis has shown.
A novel hand-powered spinning device, which employs the principles of centrifugal force and a fidget spinner toy, can perform on-site detection of urinary tract infection (UTI) in about 50 minutes and may prove useful in low-resource settings, as reported in a study.
Treatment with vibegron 75 mg once daily effectively lowers micturitions, urgency episodes, and urge incontinence and increases the volume per micturition in patients with symptoms of overactive bladder (OAB), results of an international phase III study have shown. It is also safe and well tolerated.
While most patients do not have such concerns, some young men treated for testicular cancer experience sexual dysfunction and other reproductive concerns 2 years after diagnosis, a recent study has found.
Coadministration of DHA and vitamin E supplements results in increased sperm motility, but no significant changes have been observed in sperm morphology and vitality in asthenozoospermic men, a study has shown.