Urinary tract infection (UTI) is complicated if the UTI is associated
with factors that increases colonization and decreases therapy
efficacy. Factors may include one or all of the following: Structural or
functional abnormalities of the genitourinary tract; presence of an
underlying disease that interferes with host defense mechanisms or the
patient being immunocompromised; and being infected by a multi-drug
Principles of therapy includes effective antimicrobial antimicrobial therapy, optimal management of the underlying
abnormalities or other diseases & adequate life-supporting measures.
The oral prodrug tebipenem pivoxil hydrobromide (TBP-PI-HBr) was as effective as intravenous ertapenem in clearing infection and achieving clinical cure in adult patients hospitalized with complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), shows a head-to-head comparison study, ADAPT-PO.
A novel hand-powered spinning device, which employs the principles of centrifugal force and a fidget spinner toy, can perform on-site detection of urinary tract infection (UTI) in about 50 minutes and may prove useful in low-resource settings, as reported in a study.
Pregnant women with urinary tract infections (UTIs) caused by multidrug-resistant (MDR) bacteria may be at increased risk of developing pyelonephritis, according to a single-centre, retrospective study presented at SMFM 2020.
New drug applications approved by US FDA as of 01 - 15 November 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
New drug applications approved by US FDA as of 16 - 31 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Infection could be a risk factor for stroke, with the risk for ischaemic stroke particularly high among individuals who had a urinary tract infection (UTI) 7 days prior, according to a recently published report.
Catching any type of infection, including those that affect the urinary and respiratory tracts and sepsis, could increase the chances of having subsequent acute ischaemic stroke, according to a recent study.
The four-valent ExPEC4V vaccine which contains O-antigens from the Escherichia coli (E. coli) serotypes O1A, O2, O6A, and O25B was well tolerated and immunogenic against extra-intestinal pathogenic E. coli (ExPEC) infections, according to the phase II US-based ESTELLA trial.
Many patients prescribed antibiotics for suspected urinary tract infection (UTI) in the emergency department (ED) may not actually require them, according to a single-centre study from the UK presented at ECCMID 2019.
A trial vaccine for the prevention of COVID-19 is underway with the first US participants being dosed in the Phase 1/2 clinical trial. Known as the BNT162 vaccine programme, the trials are a collaboration between Pfizer Inc. and BioNTech SE, and is part of a global development programme with Germany and the US taking the lead in having the first cohorts to be vaccinated. Germany started the study 1 week earlier.