Nonspecific urinary tract infection symptoms in infants <3 months are fever, feeding difficulties, vomiting, lethargy, irritability and failure to thrive.
Toddlers and preschoolers have unusual odor of urine, abdominal or flank pain, frequency, dysuria, and urgency.
School-age children have the classical symptoms of fever, frequency, urgency and dysuria.
Consider UTI in all seriously ill children even when there is evidence of infection outside the urinary tract.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.