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Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

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Tristan Manalac, 2 days ago
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Zolpidem-CR may benefit depressed patients with severe insomnia

04 Oct 2019

Routine prescription of a hypnotic medication does not appear to substantially reduce suicidal ideation in depressed outpatients with insomnia, but coprescription of such drug during antidepressant initiation may help suicidal outpatients, particularly those with severe insomnia, suggest the results of a study.

This 8-week, three-site, double-blind, placebo-controlled, parallel-group, randomized controlled trial compared controlled release zolpidem (zolpidem-CR) with placebo, in combination with an open-label selective serotonin reuptake inhibitor. Medication-free patients aged 18–65 years with major depressive disorder, insomnia and suicidal ideation were included.

The main outcome was suicidal ideation, measured first by the Scale for Suicide Ideation (SSI) and second by the Columbia–Suicide Severity Rating Scale (C-SSRS).

Of the 103 patients (mean age, 40.5 years; 64 women), 51 were randomized to receive zolpidem-CR and 52 to placebo.

Zolpidem-CR showed a strong anti-insomnia effect and was especially beneficial to patients with the most severe insomnia symptoms. The study drug had no significant effect on the SSI (least squares mean estimate, –0.56, 95 percent CI, –2.19 to 1.08; standard error [SE], 0.83), but the score reductions were significantly positively associated with improvement in insomnia after accounting for the effect of other depression symptoms.

On the other hand, zolpidem-CR showed a significant treatment effect (least squares mean estimate, –0.26, –0.50 to –0.02; SE, 0.12) as indicated by the C-SSRS. Of note, the treatment effect of zolpidem in reducing suicidal ideation on the C-SSRS was greater in patients with more severe insomnia.

Furthermore, there were no deaths or suicide attempts that occurred.

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Most Read Articles
Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.