Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Zolpidem-CR may benefit depressed patients with severe insomnia

04 Oct 2019

Routine prescription of a hypnotic medication does not appear to substantially reduce suicidal ideation in depressed outpatients with insomnia, but coprescription of such drug during antidepressant initiation may help suicidal outpatients, particularly those with severe insomnia, suggest the results of a study.

This 8-week, three-site, double-blind, placebo-controlled, parallel-group, randomized controlled trial compared controlled release zolpidem (zolpidem-CR) with placebo, in combination with an open-label selective serotonin reuptake inhibitor. Medication-free patients aged 18–65 years with major depressive disorder, insomnia and suicidal ideation were included.

The main outcome was suicidal ideation, measured first by the Scale for Suicide Ideation (SSI) and second by the Columbia–Suicide Severity Rating Scale (C-SSRS).

Of the 103 patients (mean age, 40.5 years; 64 women), 51 were randomized to receive zolpidem-CR and 52 to placebo.

Zolpidem-CR showed a strong anti-insomnia effect and was especially beneficial to patients with the most severe insomnia symptoms. The study drug had no significant effect on the SSI (least squares mean estimate, –0.56, 95 percent CI, –2.19 to 1.08; standard error [SE], 0.83), but the score reductions were significantly positively associated with improvement in insomnia after accounting for the effect of other depression symptoms.

On the other hand, zolpidem-CR showed a significant treatment effect (least squares mean estimate, –0.26, –0.50 to –0.02; SE, 0.12) as indicated by the C-SSRS. Of note, the treatment effect of zolpidem in reducing suicidal ideation on the C-SSRS was greater in patients with more severe insomnia.

Furthermore, there were no deaths or suicide attempts that occurred.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.