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Younger age, female gender tied to lower HRQoL in patients with kidney stone

21 Jul 2019
Raising fluid intake and drug therapy if increased fluid intake is inadequate are among the new recommendations.

Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.

Median total score for the four subdomains (ie, social functioning, emotional functioning, stone-related impact and vitality) was 80.4 for all patients. Multivariable analysis revealed a significantly higher total HRQoL in older than younger patients (per 10-year increase odds ratio [OR], 1.25; p<0.0001). In addition, male patients had higher scores than females (OR, 1.56; p=0.0003), while non-Caucasian patients had lower scores than non-Latino Caucasian patients (OR, 0.63; p=0.0045).

“The clinical impact of these findings might include future implications for patient counseling, including dietary and medical management of stone disease, and potential changes to the paradigm of the surgical management of stones,” the authors said.

This study is a subanalysis of cross-sectional data looking at the association of age, gender and race on HRQoL of stone formers. Multivariable analyses of ordinal logistic regression analyses were conducted to examine the influence of age, gender and race on HRQoL, adjusting for other baseline covariates. The authors checked the proportional odds assumption of ordinal logistic regression and included total score and scores on all subdomains.

“Kidney stone formers have lower HRQoL than nonstone formers,” the authors said. “The North American Stone Quality of Life Consortium is a multicentre, longitudinal, prospective study of HRQoL in patients with kidney stones using the WISQOL (Wisconsin Stone Quality of Life Questionnaire) with data on 2,052 patients from a total of 11 centres.”

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