Most Read Articles
Roshini Claire Anthony, 4 days ago

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6 days ago
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Yesterday
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.

Xanthelasma palpebrarum patients have higher blood LDLs, atherosclerosis risk

21 Feb 2020
Patients with xanthelasma palpebrarum (XP) have elevated serum levels of atherogenic low-density lipoprotein (LDLs) and suffer from an excess risk of atherosclerosis, reports a new meta-analysis.

Accessing the databases of Embase, the Cochrane library, Pubmed and the Web of Science, researchers retrieved 15 case-control studies eligible for meta-analysis. The cumulative cohort included 854 XP patients, with mean ages ranging from 40 to 60 years, and 907 healthy controls.

Pooled analysis found that XP patients had significantly higher total cholesterol than healthy controls (standardized mean difference [SMD], 0.612, 95 percent confidence interval [CI], 0.376–0.848; p<0.001), as well as LDLs (SMD, 0.587, 95 percent CI, 0.339–0.836; p<0.001).

Notably, even in the subpopulation of XP patients who had normal lipid profiles, concentrations of total cholesterol (SMD, 0.528, 95 percent CI, 0.058–0.997; p=0.028) and LDLs (SMD, 0.415, 95 percent CI, 0.007–0.823; p=0.046) still significantly exceeded that of the controls.

In contrast, no such differences were reported for high-density lipoproteins (SMD, –0.135, 95 percent CI, –0.345 to 0.075; p=0.207), very-low-density lipoproteins (SMD, 0.288, 95 percent CI, –0.01 to 0.585; p=0.058) and triglycerides (SMD, 0.259, 95 percent CI, –0.019 to 0.537; p=0.068). Heterogeneity of evidence was substantial for each analysis.

In turn, XP patients seemed to be at a greater risk of atherosclerosis and other cardiovascular diseases, as indicated by a significantly higher carotid intima-media thickness relative to healthy controls (SMD, 1.848, 95 percent CI, 0.639–3.057; p=0.003).

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Most Read Articles
Roshini Claire Anthony, 4 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

6 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 5 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Yesterday
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.