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Roshini Claire Anthony, 5 days ago

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Whole-grain wheat intervention protects against hepatic fat

09 Jan 2019

A 12-week whole-grain wheat (WGW) intervention prevents a substantial increase in liver fat, while a 12-week refined wheat (RW) intervention leads to higher liver fat, which may result in nonalcoholic fatty liver disease, a recent study has shown.

Both RW and WGW interventions did not affect fasting plasma cholesterol, triglycerides, nonesterified fatty acids and insulin.

There was a significant increase of 49.1 percent in intrahepatic triglycerides (IHTGs) in the RW vs the WGW group (p=0.033). Increase in IHTGs after RW could not be predicted by baseline microbiota composition. However, gut microbiota diversity decreased in the RW vs the WGW group (p=0.010).

Furthermore, postprandial triglyceride levels increased in the WGW vs the RW group (p=0.020). The WGW intervention also led to lower fasting levels of the liver acute-phase proteins serum amyloid A (p=0.057) and C-reactive protein (p=0.064) when compared to the RW intervention.

“Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health,” the authors said.

In a double-blind, parallel trial, 50 overweight men and postmenopausal women aged 45–70 years were randomized to a 12-week intervention with either WGW (98 g/d) or RW (98 g/d) products. The authors evaluated IHTGs and fat distribution before and after the intervention using proton magnetic resonance spectroscopy/imaging, faecal microbiota composition, adipose tissue gene expression and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.

“WGW is described as nutritionally superior to RW and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent,” the authors noted. “The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.”

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.