Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
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01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Which syndromic case definition is most useful for RSV infections in infants?

05 Dec 2019

The acute respiratory infection definition set by the World Health Organization (WHO) is suitable for initial screening for respiratory syncytial virus (RSV) among infants aged <6 months, while the alternative syndromic case definition is considered as the most robust for confirmation of cases in this population, suggests a study.

A total of 565 infants were tested for RSV, of whom 161 (28.5 percent) had laboratory-confirmed RSV infection. Among all case definitions evaluated, the most specific (95.8 percent, 95 percent confidence interval [CI], 93.8–97.8) was the one developed using latent class analyses (LCA; cough plus shortness of breath plus coryza plus wheeze plus poor feeding plus chest in-drawing). In addition, it also had the highest positive predictive value (51.4 percent, 95 percent CI, 34.9–68.0).

On the other hand, the WHO-acute respiratory infection (cough or sore throat or shortness of breath or coryza, plus a clinician’s judgment that illness is due to infection) was the most sensitive (98.1 percent, 95 percent CI, 96.1–100.0; negative predictive value, 96.3 percent, 95 percent CI, 92.2–100.0).

“Appropriate case definitions will vary depending on the content and setting in which they are utilized,” the authors said.

This study collected data on infants aged <6 months who were tested for RSV as part of routine clinical care at Children’s Healthcare of Atlanta between January 2010 and December 2015. The authors computed the sensitivity, specificity, and positive and negative predictive values of clinical features for existing syndromic case definitions used by the WHO and alternative ones constructed using LCA to detect RSV infection.

“RSV is a major cause of paediatric morbidity and mortality worldwide,” the authors said. “Standardized case definitions that are applicable to [a] variety of populations are critical for robust surveillance systems to guide decision-making regarding RSV control strategies including vaccine evaluation.”

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.