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Which packaging system is best for insulin detemir?

07 Apr 2021

Insulin detemir injection remains stable for at least 7 days in a closed glass vial or glass syringe and for only 3 days in a plastic syringe at room temperature, as demonstrated in a study of different primary packaging systems.

This study sought to examine the stability of insulin detemir at controlled room temperature at 25 °C in different packaging systems over 7 days.

The authors used a reverse-phase high-performance liquid chromatography (HPLC) assay method for insulin injection to determine the degradation characteristics of insulin detemir based on the assay results in different packaging systems (ie, pinhole glass vial, closed glass vial, glass syringe, and plastic syringe) at room temperature. Afterwards, they compared each packaging system to insulin detemir stored in the original packaged closed glass vial at 2–8 °C.

At the end of day 7, insulin detemir stored in a closed glass vial and a glass syringe exhibited minor degradation (98.96±1.49 percent and 99.78±0.10 percent, respectively). On the other end, insulin detemir stored in plastic syringe decreased to 94.90±2.50 percent by day 3 and to 93.52±0.29 percent by day 7. Furthermore, an increase in the assay was shown by insulin detemir stored in pinhole glass vial (152.13±0.12 percent) by day 7.

“This study will allow pharmacists in the hospital setting to deliver patient-specific insulin doses into an insulin syringe with confidence in the stability,” the authors said.

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Most Read Articles
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Pearl Toh, 19 Mar 2021
Dupilumab effectively prevents severe asthma exacerbations and improves lung function in patients with difficult-to-treat type 2 asthma, according to a post hoc analysis of the LIBERTY ASTHMA QUEST study presented at AAAAI 2021.
Elaine Soliven, 17 Mar 2021
Treatment with an intranasal budesonide aqueous spray led to significantly reduced nasal symptoms in adults with rhinitis exposed to high levels of airborne pollution, according to a study presented at AAAAI 2021.