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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
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Which antidepressants can reduce risk of acute myocardial infarction?

26 Oct 2020

Current use of antidepressants interfering selectively with the reuptake of serotonin and those antagonizing the 5‐HT2A receptor results in a reduced risk of acute myocardial infarction (AMI), a recent study has shown.

These antidepressants should be used by patients at cardiovascular risk, the authors suggested.

This nested case–control study used a primary care database over the period 2002–2015 to assess the association between antidepressants use and AMI risk. The authors identified AMI cases from a cohort of patients aged 40–99 years and randomly selected five controls per case, matched to patients for exact age, sex, and index data.

Categories for exposure to antidepressants were as follows: current, recent, past, and nonusers. Conditional logistic regression was used to examine the relationship between the current use of different antidepressants and AMI as compared to nonuse. Dose and durations effects were also explored.

Overall, 24,155 incident AMI cases and 120,775 controls were included. Current use of antidepressants as a group correlated with a decreased risk (adjusted odds ratio [AOR], 0.86, 95 percent confidence interval [CI], 0.81–0.91), but it was chiefly driven by selective serotonin reuptake inhibitors (AOR, 0.86, 95 percent CI, 0.81–0.93).

There was also a reduced AMI risk with the use of trazodone (AOR, 0.76, 95 percent CI, 0.64–0.91) and clomipramine (AOR, 0.62, 95 percent CI, 0.40–0.96). Of note, no significant effect was found with other antidepressant agents.

“A duration‐dependent effect was suggested for selective serotonin reuptake inhibitors, trazodone, and clomipramine, while there was no clear dose‐dependency,” the authors noted.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.