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11 Oct 2019
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What is the cut-off BP value for pregnant women at risk of masked hypertension?

21 Aug 2019

Having identified the prevalence and increased risk of masked hypertension in pregnant women, a recent study suggests that an office blood pressure (BP) of at least 125/75 mm Hg in the second half of gestation may be appropriate to indicate out-of-office measurements in high-risk pregnancies.

Of the 373 women (mean age, 30±7 years with 32±4 weeks of gestation), 69 (18.5 percent) developed pre-eclampsia or eclampsia. A stepwise increase was seen in the risk for pre-eclampsia or eclampsia through quartiles of systolic office BP (8.8 percent, 13.4 percent, 19.6 percent and 32.3 percent; p<0.001) and diastolic office BP (6.5 percent, 13.7 percent, 19.6 percent and 34.4 percent; p<0.001).

There was a significant increase in odds ratio (OR) through quartiles of systolic (p=0.004) and diastolic (p<0.001) office BP. The significance manifested more between the second and third quartile, with the cut-off point being 125/76 mm Hg.

The prevalence of white-coat hypertension was 3.8 percent and masked hypertension 24.7 percent. Using ambulatory BP monitoring (ABPM), 14 of 61 office hypertensive women were reclassified as having white-coat hypertension and 92 of 312 normotensive women as having masked hypertension.

Furthermore, there was a significant increase in OR for pre-eclampsia or eclampsia in women with masked hypertension.

Absolute risk for pre-eclampsia or eclampsia was comparable between women with office BP <125/75 mm Hg and those with normal ABPM (7.2 percent vs 7.1 percent).

This prospective cohort study included women in the second half of high-risk pregnancies. Participants had their office and ambulatory BP measured, and were divided according to quartiles of office BP and in normotension, white-coat hypertension, masked hypertension and sustained hypertension. The investigators then estimated the risks for pre-eclampsia or eclampsia for each category.

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Most Read Articles
11 Oct 2019
Blood transfusion occurs with a striking frequency among autologous breast reconstruction patients and is associated with an increased risk of surgery-related complications, a recent study has found.
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Tristan Manalac, 25 Aug 2017
Using blunt needles to administer local anaesthesia in upper blepharoplasty has a lower risk of haemorrhage and need for interventional pain procedures compared with sharp needles, a new randomized clinical trial has found.
09 Nov 2019
In patients with acute ST-segment elevation myocardial infarction (ASTEMI), the risk of new-onset atrial fibrillation (NOAF) appears to be linked with plasma levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), a recent China study has found.