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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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What genes are related to postmenopausal osteoporosis?

09 Jul 2020

Biological signals involved in monocyte recruitment, monocyte/macrophage lineage development, osteoclast formation, and osteoclast differentiation may work together in peripheral blood monocytes (PBMs) that contribute to the pathogenesis of postmenopausal osteoporosis, reveals a study.

The investigators sought to identify postmenopausal osteoporosis-related genes by conducting transcriptome-wide expression analyses for human PBMs using Affymetrix 1.0 ST arrays in 40 Caucasian postmenopausal women with discordant bone mineral density (BMD) levels.

A multiscale embedded gene coexpression network analysis was carried out to examine functionally orchestrating clusters of differentially expressed genes in the form of functional networks. The investigators applied gene sets net correlations analysis (GSNCA) to assess how the coexpression structure of a predefined gene set differed in high and low BMD groups.

Bayesian network (BN) analysis was used to identify important regulation patterns between potential risk genes for osteoporosis. Findings from BN analysis were validated through a small interfering ribonucleic acid (siRNA)-based gene silencing in vitro experiment.

Multiscale embedded gene coexpression network analysis revealed significantly enriched “T cell receptor signaling pathway” and “osteoclast differentiation pathway” in the identified compact network, which significantly correlated with BMD variation.

On GSNCA, the coexpression structure of the “Signaling by TGF-beta receptor complex pathway” was significantly different between the two BMD discordant groups. The hub genes in the postmenopausal low and high BMD groups were FURIN and SMAD3, respectively.

Of note, the regulation relationship of TGFBR2SMAD7 and TGFBR1SMURF2 was confirmed with siRNA in vitro experiments.

“Menopause is a crucial physiological transition during a woman’s life, and it occurs with growing risks of health issues like osteoporosis,” the investigators said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.