Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

What factors correlate with residual disease activity in psoriatic arthritis?

05 Nov 2020

Patients with psoriatic arthritis (PsA) may show residual disease activity (RDA), according to a study. Very low disease activity (VLDA) appears to be the most stringent criterion to identify patients in the absence of RDA.

PsA patients were eligible if they satisfied ClASsification for Psoriatic ARthritis (CASPAR) criteria with >6 months’ follow-up and achieved a status of low disease activity (LDA), minimal disease activity (MDA), or remission (Disease Activity Index for PsA [DAPSA] remission or VLDA).

The authors assessed RDA by the percentage of patients who, although in LDS or remission, had tender or swollen joints >1, Leeds Enthesitis Index >1, Health Assessment Questionnaire >0.5, Psoriasis Area Severity Index (PASI) >1, patient’s global assessment >20, physician visual analogue scale (VAS) >20, and VAS pain >15. They also evaluated the factors associated with RDA.

Among 113 eligible patients with PsA, 78 (69 percent) were in MDA while 46 (40.7 percent) had DAPSA remission and only 32 (28.3 percent) were in VLDA. The most stringent composite index was VLDA, with a minimal RDA only in the VAS physician in one patient (3.1 percent) and none in the different domains. On the other hand, patients in MDA had RDA in tender joints (14.1 percent), VAS pain (29.4 percent), and PASI >1 or body surface area (BSA) >3 percent (17.9 percent).

Notably, patients in DAPSA remission had a very low rate of RDA in almost all domains, but 12 (26 percent) of them showed a PASI >1 or BSA >3 percent. LDA also displayed RDA in higher percentages, particularly in patient-reported outcomes, tender joints, and skin domain, according to the authors.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).