Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

What are the predictors of melanoma after allogeneic HCT?

31 Aug 2020

Adherence to current surveillance guidelines, such as routine skin examination and photoprotection recommendations, is essential among survivors of haematopoietic cell transplantation (HCT) at highest risk for the development of cutaneous melanoma, suggests a recent study.

The investigators determined the risk factors for melanoma following allogeneic HCT by performing a nested case-control study of 140 melanoma patients and 557 controls (matched by age at HCT, sex, primary disease, and survival time) through the Center for International Blood and Marrow Transplant Research.

The risk of melanoma was significantly elevated among HCT survivors who received total body irradiation-based myeloablative conditioning (multivariable-adjusted odds ratio [OR], 1.77, 95 percent confidence interval [CI], 1.00–3.15) or reduced-intensity conditioning containing melphalan (OR, 2.60, 95 percent CI, 1.13–6.02) or fludarabine (OR, 2.72, 95 percent CI, 1.02–7.30) compared with busulfan-based myeloablative regimens.

Melanoma risk was also increased among HCT survivors who were diagnosed with acute graft-versus-host disease (GVHD) with stage 2+ skin involvement (OR, 1.92, 95 percent CI, 1.19–3.10), chronic GVHD without skin involvement (OR, 1.91, 95 percent CI, 1.03–3.57), or keratinocytic carcinoma (OR, 2.37, 95 percent CI, 1.16–4.83), as well as those residing in areas with higher ambient ultraviolet radiation (tertile 3 OR, 1.64, 95 percent CI, 1.01–2.67).

This study was limited by the lack of data on individual-level ultraviolet radiation exposure and clinical data on melanoma characteristics, according to the investigators, adding that misclassification of melanoma was possible since not all pathology reports were available for review.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.