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Weight gain ups cancer risk among middle-aged individuals

11 Jul 2018

Individuals who gain weight during middle life appear to be at greater risk of developing obesity-related cancer irrespective of metabolic function and body mass index (BMI), according to a study.

Researchers examined independent and combined effects of weight gain and metabolic dysfunction during middle-adult years on obesity-related cancer risk in a cohort of 3,850 individuals (aged 45–69 years) from the Framingham Offspring Study.

Obesity-related cancer outcomes included those that involved the female reproductive organs (postmenopausal breast, uterine/endometrial and ovarian), colon, rectum, stomach, liver, gallbladder, pancreas, kidney, thyroid, oesophageal adenocarcinoma, leukaemia, non-Hodgkin lymphoma and multiple myeloma.

During about 14 years of follow up, 145 men and 90 women lost ≥0.45 kg/years (mean weight loss, –0.72 and –0.77 lbs/year, respectively), and 530 men and 805 women gained 0.45 kg/year (mean weight gain, 0.81 and 0.80 kg/year, respectively). Weight remained stable in 1,166 men and 1,112 women.

Compared with maintaining stable weight, gaining ≥0.45 kg/year over about 14 years was associated with a 38-percent increased cancer risk (hazard ratio [HR], 1.38; 95 percent CI, 1.09–1.76). Of note, the elevated cancer risk associated with weight gain increased by 77 percent in men and women with metabolic dysfunction (HR, 1.77; 1.21–2.59).

Compared with nonoverweight adults, men and women who became overweight (BMI 30 and 25 kg/m2, respectively) during midlife also had increased cancer risk (men: HR, 2.18; 1.33–3.56; women: HR, 1.60; 1.12–2.28).

The risk increased by 28 percent and 33 percent, although not significantly, in men and women who were already overweight at baseline. This is despite having a midlife BMI that was higher by 3.4 kg/m2 than the midlife BMI of those who gained weight later.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 6 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
4 days ago
The simple Atrial fibrillation (AF) Better Care (ABC) pathway holistically updates the integrated care for AF patients and helps reduce the risk of adverse outcomes such as all-cause mortality, stroke/major bleeding/cardiovascular death and hospitalization, according to a study.
Yesterday
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.