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07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.
Roshini Claire Anthony, 06 Oct 2020

Several strategies have been proposed to help manage the adverse events (AEs) that emerged during the BEACON CRC trial which assessed the effect of encorafenib plus cetuximab in patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) who had progressed after one or two prior regimens.

Weekly exenatide for type 2 diabetes delivers in real world

2 days ago

Exenatide once weekly (EOW) provides effective glucose control and weight loss in patients with type 2 diabetes mellitus (T2DM), and these benefits are sustained through 18 months of treatment, according to real-world data.

The analysis included 186 patients (mean age, 63.2 years; 46.2 percent male; diabetes duration, 10.7 years) treated with EOW 2 mg in a real-world setting. These patients attended follow-up visits at 6, 12, and 18 months after treatment initiation.

After 6 months of treatment, HbA1c values dropped significantly (−0.9 percent, 95 percent confidence interval [CI], −1.1 to −0.8), as well as body weight (−2.8 kg, 95 percent CI, −3.4 to −2.2). More than half of the population (61 percent) achieved target HbA1c values of ≤7 percent, while 34 percent shed at least 5 percent of their baseline body weight at the 12-month follow up.

The reductions in blood sugar and weight were maintained at 18 months.

Shorter diabetes duration and nonuse of a different glucagon-like peptide-1 receptor agonist (GLP-1RA) predicted adequate glycaemic and weight response, respectively. Of note, patients on sulfonylureas failed to reach metabolic and body weight targets.

Gastrointestinal side effects (7.5 percent) and injection site reactions (6.4 percent) were the most common adverse events. A fraction of patients developed headache (1.1 percent) and allergic reactions (1.1 percent).

Treatment was discontinued in 79 patients (43 percent) because of insufficient HbA1c improvement and/or limited weight reduction (19.9 percent), side effects (16.1 percent), or patient decision (6.5 percent). Higher baseline HbA1c levels and use of basal insulin therapy prior to treatment initiation predicted EOW discontinuation.

The findings suggest that early initiation of EOW could improve glycaemic control and lower the risk of treatment discontinuation.

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Most Read Articles
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.
Roshini Claire Anthony, 06 Oct 2020

Several strategies have been proposed to help manage the adverse events (AEs) that emerged during the BEACON CRC trial which assessed the effect of encorafenib plus cetuximab in patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) who had progressed after one or two prior regimens.