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Water supplementation lowers copeptin, plasma glucose in adults with high copeptin

26 Apr 2019

Water supplementation in individuals with habitually low water consumption and high levels of copeptin is a safe and effective intervention in reducing copeptin, suggests a recent study, adding that this may help lower fasting plasma glucose and reduce the risk of diabetes.

There was an increase in reported mean water intake from 0.43 to 1.35 L · d−1 (p<0.001), without any observed changes in diet.

Median urine osmolality decreased from 879 (interquartile range [IQR], 705-996) to 384 (IQR, 319–502) mOsm · kg−1 (p<0.001), while urine volume increased from 1.06 (IQR, 0.90–1.20) to 2.27 (IQR, 1.52–2.67) L · d−1 (p<0.001) and baseline copeptin decreased from 12.9 (IQR, 7.4–21.9) to 7.8 (IQR, 4.6–11.3) pmol · L−1 (p<0.001).

Water supplementation led to lower fasting plasma glucose from a mean of 5.94 (SD, 0.44) to 5.74 (SD, 0.51; p=0.04). Participants in the top tertile of baseline copeptin showed the most significant water-related reduction of both fasting copeptin and glucose concentration in plasma.

“Further investigations are warranted to support these findings,” the authors said.

This study included 31 healthy adults with high copeptin (>10.7 pmol · L−1 in men and >6.1 pmol · L−1 in women) identified in a population-based survey conducted from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg−1.

Participants had an addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks. Pre- and postintervention fasting plasma copeptin concentrations were the main outcome measures.

Copeptin is a marker of vasopressin and associated with low water intake and high diabetes risk, according to the authors.

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Most Read Articles
09 May 2019
Nurses who utilize the pen device take less time preparing and administering insulin compared with those who use the vial and syringe method, reports a recent study.
6 days ago
Excessive gains in overall and central fat prior to the childbearing period pose an increased risk of developing gestational diabetes mellitus, a study has found.
24 Apr 2019
Severe vitamin D deficiency may be detrimental to diabetic patients, with the condition increasing the risk of diabetic foot ulcer, according to the results of a meta-analysis.
6 days ago
New drug applications approved by US FDA as of 01 - 15 May 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.