Walking before dinner does not translate to 24-h glucose profile improvements
Doing a single bout of walking before dinner has little to no benefits in terms of 24-hour glucose profiles, with the notable exception of a reduction in glucose during the activity itself, according to the results of the E-Paradigm* study.
A total of 80 participants were assigned to two experimental conditions—exercise and nonexercise (control)–separated by 72 hours in a randomized crossover design. Each condition lasted 2 days, during which standardized meals were provided.
Exercise involved 50 minutes of treadmill walking at 5.0 km/h before the evening meal, whereas control consisted of sitting for 50 minutes. Mean glucose during the 24-hour period following exercise (or sitting), measured using continuous glucose monitoring, was the primary outcome.
Of the participants, 73 completed both exercise and control. However, only 63 participants (mean age, 64 years; 54 percent female) observed complied with the standardized diets and had complete continuous glucose monitoring data. Their mean baseline body mass index [BMI] and HbA1c were 30.5 kg/m2 and 51 mmol/mol (6.8 percent), respectively.
Mean 24-h glucose did not improve with exercise vs sitting (0.03 mmol/L, 95 percent CI, –0.17 to 0.22; p=0.778), but individual differences between conditions ranged from –2.8 to 1.8 mmol/L. Likewise, exercise had no significant effect on fasting glucose, postprandial glucose or glucose variability.
There was a notable reduction in glucose concentrations during the 50 minutes of walking vs sitting (–1.56 mmol/L, –2.18 to –0.95; p<0.001).
Researchers pointed out that the E-Paradigm protocol was feasibly implemented across multiple sites and could be implemented in other settings to evaluate responses among individuals with different characteristics or in response to other exercise interventions.
*Exercise-Physical Activity and Diabetes Glucose Monitoring