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Roshini Claire Anthony, 08 Apr 2019

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Walking before dinner does not translate to 24-h glucose profile improvements

21 Jul 2019

Doing a single bout of walking before dinner has little to no benefits in terms of 24-hour glucose profiles, with the notable exception of a reduction in glucose during the activity itself, according to the results of the E-Paradigm* study.

A total of 80 participants were assigned to two experimental conditions—exercise and nonexercise (control)–separated by 72 hours in a randomized crossover design. Each condition lasted 2 days, during which standardized meals were provided.

Exercise involved 50 minutes of treadmill walking at 5.0 km/h before the evening meal, whereas control consisted of sitting for 50 minutes. Mean glucose during the 24-hour period following exercise (or sitting), measured using continuous glucose monitoring, was the primary outcome.

Of the participants, 73 completed both exercise and control. However, only 63 participants (mean age, 64 years; 54 percent female) observed complied with the standardized diets and had complete continuous glucose monitoring data. Their mean baseline body mass index [BMI] and HbA1c were 30.5 kg/m2 and 51 mmol/mol (6.8 percent), respectively.

Mean 24-h glucose did not improve with exercise vs sitting (0.03 mmol/L, 95 percent CI, –0.17 to 0.22; p=0.778), but individual differences between conditions ranged from –2.8 to 1.8 mmol/L. Likewise, exercise had no significant effect on fasting glucose, postprandial glucose or glucose variability.

There was a notable reduction in glucose concentrations during the 50 minutes of walking vs sitting (–1.56 mmol/L, –2.18 to –0.95; p<0.001).

Researchers pointed out that the E-Paradigm protocol was feasibly implemented across multiple sites and could be implemented in other settings to evaluate responses among individuals with different characteristics or in response to other exercise interventions.

*Exercise-Physical Activity and Diabetes Glucose Monitoring

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Most Read Articles
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

14 Aug 2019
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
06 Aug 2019
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.