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Jairia Dela Cruz, 09 Aug 2019
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Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

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Walking before dinner does not translate to 24-h glucose profile improvements

21 Jul 2019

Doing a single bout of walking before dinner has little to no benefits in terms of 24-hour glucose profiles, with the notable exception of a reduction in glucose during the activity itself, according to the results of the E-Paradigm* study.

A total of 80 participants were assigned to two experimental conditions—exercise and nonexercise (control)–separated by 72 hours in a randomized crossover design. Each condition lasted 2 days, during which standardized meals were provided.

Exercise involved 50 minutes of treadmill walking at 5.0 km/h before the evening meal, whereas control consisted of sitting for 50 minutes. Mean glucose during the 24-hour period following exercise (or sitting), measured using continuous glucose monitoring, was the primary outcome.

Of the participants, 73 completed both exercise and control. However, only 63 participants (mean age, 64 years; 54 percent female) observed complied with the standardized diets and had complete continuous glucose monitoring data. Their mean baseline body mass index [BMI] and HbA1c were 30.5 kg/m2 and 51 mmol/mol (6.8 percent), respectively.

Mean 24-h glucose did not improve with exercise vs sitting (0.03 mmol/L, 95 percent CI, –0.17 to 0.22; p=0.778), but individual differences between conditions ranged from –2.8 to 1.8 mmol/L. Likewise, exercise had no significant effect on fasting glucose, postprandial glucose or glucose variability.

There was a notable reduction in glucose concentrations during the 50 minutes of walking vs sitting (–1.56 mmol/L, –2.18 to –0.95; p<0.001).

Researchers pointed out that the E-Paradigm protocol was feasibly implemented across multiple sites and could be implemented in other settings to evaluate responses among individuals with different characteristics or in response to other exercise interventions.

*Exercise-Physical Activity and Diabetes Glucose Monitoring

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Most Read Articles
Jairia Dela Cruz, 09 Aug 2019
Uric acid-lowering therapy for gout also confers benefits for hyperlipidaemia, with febuxostat delivering greater reductions in cholesterol and triglyceride concentrations in the blood as compared with allopurinol and benzbromarone, according to a recent study.
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

31 Jul 2019
New drug applications approved by US FDA as of 16 - 31 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
6 days ago
Chronic exposure to higher cortisol levels among patients with Turner syndrome (TS) is linked to short stature and greater total cholesterol levels, according to a study. Cortisol exposure also contributes to an increase in cardiovascular disease risk.