Most Read Articles
Stephen Padilla, 4 days ago
Diabetic patients in a decompensated state and who develop type 2 myocardial infarction (MI) have an increased risk for mortality and major adverse cardiac events (MACE), according to a new study. In addition, these patients are potentially at risk for undiagnosed coronary artery disease.
6 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 13 Jul 2018
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
6 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.

Waist-to-hip ratio tied to MACE risk in females with coronary artery disease

14 Apr 2018

There appears to be a link between waist-to-hip ratio (WHR) and higher risks of major adverse cardiac events (MACEs) in females with coronary artery disease, according to a recent study.

Over a median follow-up of 5.7 years, 415 patients experienced at least 1 MACE event. Multivariate models showed that females in the highest WHR tertile had significantly higher risk of MACE relative to those in the lowest tertile (hazard ratio [HR], 1.85; 95 percent CI, 1.16–2.94; p=0.01).

Treating WHR as a continuous variable resulted in a similar trend. Each 0.10-unit rise in WHR was associated with a significant increase in the risk of MACEs in females (HR, 1.32; 1.08–1.61; p=0.007). All associations were robust to adjustments for body mass index (BMI)

In contrast, central obesity, as measured by WHR, did not seem to significantly affect MACE risk in males (HR for third vs first tertile, 0.92; 0.69–1.22; p=0.54; HR for each 0.10-unit increase in WHR, 0.98; 0.85-1.13; p=0.81).

The study included 1,529 CAD patients (mean age 63.1±12.5 years; 74 percent male) referred to cardiac rehabilitation. Participants were classified according to BMI groups and sex-specific tertiles of WHR. A composite outcome of stroke, death, ventricular arrhythmia, revascularization and acute coronary syndrome was used to define MACEs.

Clinically, “[a]n early assessment of central adiposity in addition to BMI and application of lifestyle changes focused on caloric balance, healthy nutrition and tailored exercise prescription may have a positive impact on [CAD] patients,” said researchers.
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 4 days ago
Diabetic patients in a decompensated state and who develop type 2 myocardial infarction (MI) have an increased risk for mortality and major adverse cardiac events (MACE), according to a new study. In addition, these patients are potentially at risk for undiagnosed coronary artery disease.
6 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 13 Jul 2018
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
6 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.