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Waist-to-hip ratio tied to MACE risk in females with coronary artery disease

14 Apr 2018

There appears to be a link between waist-to-hip ratio (WHR) and higher risks of major adverse cardiac events (MACEs) in females with coronary artery disease, according to a recent study.

Over a median follow-up of 5.7 years, 415 patients experienced at least 1 MACE event. Multivariate models showed that females in the highest WHR tertile had significantly higher risk of MACE relative to those in the lowest tertile (hazard ratio [HR], 1.85; 95 percent CI, 1.16–2.94; p=0.01).

Treating WHR as a continuous variable resulted in a similar trend. Each 0.10-unit rise in WHR was associated with a significant increase in the risk of MACEs in females (HR, 1.32; 1.08–1.61; p=0.007). All associations were robust to adjustments for body mass index (BMI)

In contrast, central obesity, as measured by WHR, did not seem to significantly affect MACE risk in males (HR for third vs first tertile, 0.92; 0.69–1.22; p=0.54; HR for each 0.10-unit increase in WHR, 0.98; 0.85-1.13; p=0.81).

The study included 1,529 CAD patients (mean age 63.1±12.5 years; 74 percent male) referred to cardiac rehabilitation. Participants were classified according to BMI groups and sex-specific tertiles of WHR. A composite outcome of stroke, death, ventricular arrhythmia, revascularization and acute coronary syndrome was used to define MACEs.

Clinically, “[a]n early assessment of central adiposity in addition to BMI and application of lifestyle changes focused on caloric balance, healthy nutrition and tailored exercise prescription may have a positive impact on [CAD] patients,” said researchers.
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Most Read Articles
4 days ago
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 2 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
2 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Yesterday
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.