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VTE common in patients with pemphigus

23 Jul 2017

Patients with pemphigus are prone to venous thromboembolism (VTE), even more so during the first year after diagnosis, according to a recent study.

To investigate the incidence and characteristics of VTE in patients with pemphigus, researchers conducted a retrospective study following a cohort of 172 patients with newly diagnosed pemphigus for the development of VTE.

VTE developed at a median of 4 months from pemphigus diagnosis in 10 patients (6 percent) over a mean follow-up time of 4 years. The first year saw the highest risk at five VTE events per 100 patient-years or a 5-percent risk of VTE for that first year.

Of the 10 patients who developed VTE, five had deep vein thrombosis, four had pulmonary embolisms and one had both. The risk of VTE was not associated with both age and gender.

Most patients had either hereditary or acquired VTE risk factors as the result of pemphigus treatments and their complications, including hospitalization, immobilization and infections.

“VTE risk must be assessed in all patients, especially when hospitalized, and thrombo-prophylaxis should be initiated in qualifying cases,” researchers said.

This study is limited by the use of existing health records, which restricted the assessment of asymptomatic VTE and VTE risk factors. In addition, the investigators failed to study the matched control population.

“VTE has been reported to be a significant cause of death in patients with pemphigus,” according to researchers.

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Mark Lester Romulo Sotelo, 01 Sep 2011
Anti-fungal agents, like Ketoconazole, have long been established as therapeutic agents for tinea infection. Its prophylactic use though, is yet to be established.
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