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Vortioxetine safe but confers no benefit for GAD symptoms

17 Jan 2020

In the management of patients with generalized anxiety disorder (GAD), vortioxetine proves to be safe and well tolerated but exerts neutral effects on GAD symptoms, quality of life (QoL) and functional status, according to the results of a meta-analysis.

Researchers searched multiple online databases for randomized controlled trials evaluating the effect of vortioxetine treatment vs placebo in patients with GAD. The search yielded four studies to be included in the meta-analysis.

Pooled data showed that compared with placebo, treatment with vortioxetine at multiple doses did not significantly improve the response rates (2.5 mg/day: odds ratio [OR], 1.16, 95 percent confidence interval [CI], 0.84–1.60; p=0.38; 5 mg/day: OR, 1.41, 95 percent CI, 0.82–2.41; p=0.21; 10 mg/day: OR, 1.05, 95 percent CI, 0.76–1.46; p=0.75).

Moreover, outcomes such as remission, discontinuation for any reason, withdrawal due to adverse events rates, Short-Form 36 Health Survey scores and Sheehan Disability Scale scores were similar between the active drug (at any dose) and placebo.

The researchers advised cautious interpretation and translation of the present data, given that the meta-analysis was based on a limited number of trials. Furthermore, the trials had a relatively short treatment duration (8 weeks), which “is an important issue because patients with GAD typically require long-term pharmacological treatment.”

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Most Read Articles
2 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.