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Vitiligo ups risk of spontaneous abortion

06 Nov 2018

A significant association exists between vitiligo and an increased risk of spontaneous abortion, according to a recent study.

Compared with the control group, patients with vitiligo showed a significantly lower live birth rate (odds ratio [OR], 0.870; 95 percent CI, 0.816–0.927) and a higher incidence of spontaneous abortion (OR, 1.250; 1.148–1.362).

“Further studies are needed to determine whether systemic autoimmunity explains our finding,” the authors said.

In a previous study on abortion, Hogue found that women who chose to have their first pregnancy terminated were at no increased risk of failing to conceive at a later date, except for abortions complicated by infection leading to pelvic inflammation disease. In addition, abortion by vacuum aspiration did not increase the risk of subsequent ectopic pregnancy. [Clin Obstet Gynaecol 1986;13:95-103]

In the present retrospective cohort study, 4,738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo were analysed using the Korean National Health Insurance Claims database from 2007 to 2016.

The associations between vitiligo and pregnancy outcomes, such as live births, spontaneous abortion, caesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia and intrauterine growth retardation were examined using multivariate logistic regression models.

The study was limited by the lack of detailed clinical information on individual patients in the Korean National Health Insurance Claims database.

“Vitiligo is a chronic autoimmune skin disorder affecting 1 percent of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo,” the authors said.

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Roshini Claire Anthony, 09 Nov 2018

Patients with advanced, unresectable melanoma may derive overall survival (OS) and progression-free survival (PFS) benefits when treated with a nivolumab plus ipilimumab combination or nivolumab alone, according to 4-year results of the phase III CheckMate 067* trial presented at ESMO 2018.

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New drug applications approved by US FDA as of 1 - 15 October 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.