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Jairia Dela Cruz, 2 days ago
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Vitamins C, E stave off nonalcoholic fatty liver disease/steatohepatitis

26 Dec 2019
Dr Paul Marik claims that an IV drip of Vitamin C, steroids and thiamine, will treat sepsis effectively.

Dietary intake of vitamins C and E may help protect against liver damage associated with nonalcoholic fatty liver disease (NAFLD), a recent study has shown.

Researchers conducted a cross-sectional analysis of 789 participants (mean age, 58.83±6.58 years; 52.6 percent male), in whom NAFLD was detected through ultrasonography. A food frequency questionnaire was used to evaluate nutritional intake.

Majority (73.6 percent; n=581) were able to meet the recommended daily intake level of vitamin C, while only 25.2 percent (n=199) met the same guidelines for vitamin E intake. Fifty-two participants (6.6 percent) used vitamin supplements. Both NAFLD and nonalcoholic steatohepatitis (NASH) occurred at greater frequencies in patients with vitamins C and E intake <1,000 kcal.

Multivariate logistic regression analysis found that in the upper tertile of vitamin E intake, each additional 1,000-kcal of vitamin E correlated with a significant drop in the risk of NASH (odds ratio [OR], 0.64, 95 percent confidence interval [CI], 0.43–0.94; p=0.024). No effect was reported for NAFLD or presumed fibrosis.

The same was true for reaching the recommended intake levels of vitamin E (OR, 0.48, 95 percent CI, 0.30–0.77; p=0.002).

Vitamin C also exerted a protective effect. In the upper tertile of intake levels, every additional 1,000-kcal of vitamin C reduced the likelihood of both NAFLD (OR, 0.68, 95 percent CI, 0.47–0.99; p=0.045) and NASH (OR, 0.57, 95 percent CI, 0.38–0.84; p=0.004). However, satisfying the recommended intake levels did not seem to yield a significant benefit.

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Most Read Articles
Jairia Dela Cruz, 2 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
11 Sep 2020
Men who use calcium channel blockers (CCBs) are at risk of developing prostate cancer, and the risk increases with the duration of CCB exposure, according to the results of a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
4 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.