Most Read Articles
Jairia Dela Cruz, 6 days ago
Use of aspirin in the primary prevention of cardiovascular disease (CVD) in patients with no prior CVD history yields protection against the risks of acute myocardial infarction (AMI) and ischaemic stroke, but at the expense of an increase of similar magnitude in the incidence of major bleeding, according to the results of a recent meta-analysis presented at the European Society of Cardiology (ESC) Congress 2019 in Paris, France.
Dr Margaret Shi, 5 days ago

A comprehensive model of care delivered by nonphysician health workers (NPHWs), involving primary care physicians and families that was informed by local context, substantially improved blood pressure (BP) control and cardiovascular disease (CVD) risk, according to results of the HOPE 4 trial reported at the European Society of Cardiology (ESC) Congress 2019 and World Congress of Cardiology (WCC) 2019.

Vitamin E lowers SBP but not DBP, mean arterial pressure

13 Mar 2019

Vitamin E supplementation does not appear to contribute to blood pressure (BP) improvement, with results of a recent systematic review and meta-analysis showing decreases only in systolic (S)BP but no favourable effect on diastolic (D)BP and mean arterial pressure (MAP).

The investigators searched PubMed/Medline, Scopus and Google scholar up to March 2018 to identify studies that evaluated the effect of vitamin E supplementation on SBP, DBP and MAP. Weighted mean differences (WMD) and 95 percent CI were expressed as effect size.

Potential sources of heterogeneity were assessed by conducting a prespecified subgroup analysis. Meta-regression analyses were conducted to examine the relationship between BP-lowering effects of vitamin E and duration of follow-up and treatment dose.

A total of 18 trials comprising 839 participants were included in the meta-analysis. Compared to placebo, vitamin E supplementation significantly decreased SBP (WMD, –3.4 mm Hg; 95 percent CI, –6.7 to –0.11; p<0.001), with a high heterogeneity across the studies (I2, 94.0 percent; p<0.001). In addition, vitamin E supplementation showed no significant effects on DBP and MAP.

A review by Sozen and colleagues stated that vitamin E is “an important nutrient influencing key cellular and molecular mechanisms, as well as gene expression regulation centrally involved in the prevention of cardiovascular disease (CVD)”, which is one of the major causes of morbidity and mortality globally. [IUBMB Life 2019;71:507-515]

“In recent years, the physiological metabolites of vitamin E, including the liver derived (long- and short-chain) metabolites and phosphorylated (α-, γ-tocopheryl phosphate) forms, have also provided novel mechanistic insight into CVD regulation that expands beyond the vitamin E precursor. It is certain that this emerging insight into the molecular and cellular action of vitamin E will help to design further studies, either in animal models or clinical trials, on the reduction of risk for CVDs,” they said.

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Most Read Articles
Jairia Dela Cruz, 6 days ago
Use of aspirin in the primary prevention of cardiovascular disease (CVD) in patients with no prior CVD history yields protection against the risks of acute myocardial infarction (AMI) and ischaemic stroke, but at the expense of an increase of similar magnitude in the incidence of major bleeding, according to the results of a recent meta-analysis presented at the European Society of Cardiology (ESC) Congress 2019 in Paris, France.
Dr Margaret Shi, 5 days ago

A comprehensive model of care delivered by nonphysician health workers (NPHWs), involving primary care physicians and families that was informed by local context, substantially improved blood pressure (BP) control and cardiovascular disease (CVD) risk, according to results of the HOPE 4 trial reported at the European Society of Cardiology (ESC) Congress 2019 and World Congress of Cardiology (WCC) 2019.