Most Read Articles
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

14 Aug 2019
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
06 Aug 2019
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
15 Feb 2018
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.

Vitamin D3 supplementation not an effective defence strategy against diabetes

14 Aug 2019

Supplementation with vitamin D3 at a dose of 4,000 IU per day does not significantly stave off the risk of diabetes in high-risk individuals with or without vitamin D insufficiency, according to data from the Vitamin D and Type 2 Diabetes (D2D) trial.

D2D randomized 2,423 adults free of diabetes but who met at least two of three glycaemic criteria for prediabetes (fasting plasma glucose level, 100–125 mg/dl; plasma glucose level 2 hours after a 75-g oral glucose load, 140–199 mg/dl; and HbA1c level, 5.7–6.4 percent) to receive either 4,000 IU per day of vitamin D3 (n=1,211) or placebo, regardless of the baseline serum 25-hydroxyvitamin D level.

By month 24, the mean serum 25-hydroxyvitamin D level increased in the vitamin D group (from 27.7 ng/ml at baseline to 54.3 ng/ml) but remained stable in the placebo group (from 28.2 ng/ml at baseline to 28.8 ng/ml).

Over a median follow-up of 2.5 years, the primary outcome of new-onset diabetes occurred in 293 participants in the vitamin D group and 323 in the placebo group, resulting in incidence rates of 9.39 and 10.66 events per 100 person-years, respectively. Cox analysis showed that vitamin D supplementation did not lead to a significant reduction in the risk of incident diabetes (hazard ratio, 0.88, 95 percent CI, 0.75–1.04; p=0.12).

The incidence of adverse events (AEs) such as hypercalcaemia, fasting urine calcium:creatinine ratio of >0.375, low estimated glomerular filtration rate and nephrolithiasis, was comparable between the two groups. Overall, AEs led to trial withdrawal in 47 participants (3.9 percent) in the vitamin D group vs 37 (3.1 percent) in the placebo group (difference, 0.8 percentage points).

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Most Read Articles
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

14 Aug 2019
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
06 Aug 2019
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
15 Feb 2018
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.