Vitamin D therapy improves sexual function in women
A recent study has shown the efficacy of vitamin D therapy in improving sexual function in women with sexual dysfunction and vitamin D deficiency. Moreover, an improvement in depression symptoms does not appear to facilitate this effect.
Women aged 18–45 years with sexual dysfunction, defined as a Female Sexual Functioning Index (FSFI) score <26.55, and serum 25[OH]D <30 ng/ml were recruited in this randomized, double-blind, placebo-controlled trial that examined the effect of vitamin D therapy on sexual function.
Participants received either an intramuscular injection of 300,000 IU cholecalciferol or a placebo at baseline and then after 4 weeks. FSFI was used to assess sexual function at baseline and at 4 and 8 weeks. The authors measured the serum level of 25[OH]D and evaluated depression symptoms using the Beck Depression Inventory (BDI) at baseline and 8 weeks.
There were 38 women in each group who completed the study. Only those in the cholecalciferol group showed an increase in serum 25[OH]D levels by a mean of 14.4±3.2 ng/ml (p<0.001).
The intervention group also registered a higher FSFI score compared with the placebo group at week 4 (19.6 vs 16.3; p=0.002) and week 8 (25.0 vs 17.1; p<0.001). A significant reduction in BDI score was achieved by participants in the cholecalciferol group (mean, –21.0±12.3; p<0.001).
“The effect of treatment on sexual function was independent of its effect on depression symptoms,” the authors said.