Vitamin D therapy improves female sexual function
Women with deficient vitamin D levels and sexual dysfunction may benefit from vitamin D supplementation, which has been shown to yield improvements in sexual function.
In a recent study, 76 women aged 18-45 years with sexual dysfunction (Female Sexual Functioning Index [FSFI] score <26.55) and a serum 25-hydroxyvitamin D (25(OH)D) level of <30 ng/mL were randomized to receive an intramuscular injection of 300,000 IU cholecalciferol (n=38) or a placebo (n=38). Treatment was administered at baseline and after 4 weeks.
FSFI was evaluated at baseline and then after 4 and 8 weeks, whereas serum 25(OH)D levels and depression symptoms (Beck Depression Inventory) were evaluated at baseline and at 8 weeks.
At week 8, serum levels of 25(OH)D increased by a mean of 14.4 ng/mL in the cholecalciferol group (p<0.001) but not in the placebo group.
Moreover, compared with placebo, cholecalciferol supplementation led to a significant increase in the FSFI score at weeks 4 (19.6 vs 16.3; p=0.002) and 8 (25.0 vs 17.1; p<0.001).
The Beck Depression Inventory score decreased by –21.0 in the cholecalciferol group (p<0.001), while no changes occurred in the placebo group.
Of note, the effect of treatment on sexual function was independent from the observed effect on symptoms of depression.