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Vitamin D therapy improves female sexual function

03 Dec 2018

Women with deficient vitamin D levels and sexual dysfunction may benefit from vitamin D supplementation, which has been shown to yield improvements in sexual function.

In a recent study, 76 women aged 18-45 years with sexual dysfunction (Female Sexual Functioning Index [FSFI] score <26.55) and a serum 25-hydroxyvitamin D (25(OH)D) level of <30 ng/mL were randomized to receive an intramuscular injection of 300,000 IU cholecalciferol (n=38) or a placebo (n=38). Treatment was administered at baseline and after 4 weeks.

FSFI was evaluated at baseline and then after 4 and 8 weeks, whereas serum 25(OH)D levels and depression symptoms (Beck Depression Inventory) were evaluated at baseline and at 8 weeks.

At week 8, serum levels of 25(OH)D increased by a mean of 14.4 ng/mL in the cholecalciferol group (p<0.001) but not in the placebo group.

Moreover, compared with placebo, cholecalciferol supplementation led to a significant increase in the FSFI score at weeks 4 (19.6 vs 16.3; p=0.002) and 8 (25.0 vs 17.1; p<0.001).

The Beck Depression Inventory score decreased by –21.0 in the cholecalciferol group (p<0.001), while no changes occurred in the placebo group.

Of note, the effect of treatment on sexual function was independent from the observed effect on symptoms of depression.

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Most Read Articles
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.