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Vitamin D supplementation may benefit hypercholesterolaemia patients

05 Sep 2019

Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol (LDL-C) and triglyceride but not high-density lipoprotein cholesterol (HDL-C), suggesting its usefulness for mitigating the risk of cardiovascular disease (CVD) in patients with hypercholesterolaemia, according to the results of a meta-analysis.

The meta-analysis included 41 randomized clinical trials (RCTs) comprising 3,434 participants (mean age, 55 years; 63.4 percent female), among whom 1,699 received vitamin D supplementation and 1,735 placebo. Approximately 24 percent of the trials had follow-up duration of >6 months, whereas the majority (76 percent) had shorter follow-up.

Of the trials, 21 involved participants with diabetes, 13 included apparently healthy participants and three were conducted on those who were obese or overweight. Mean vitamin D supplement per day was 2,795 IU.

Pooled data revealed that compared with placebo, vitamin D supplementation produced reductions in the following: total cholesterol (standardized mean difference [SMD], –0.17, 95 percent CI, –0.28 to –0.06; I2, 54.6 percent), LDL-C (SMD, –0.12, –0.23 to –0.01; I2, 52 percent), triglycerides (SMD, –0.15, –0.24 to –0.06; I2, 32.9 percent). On the other hand, the effect of supplementation on HDL-C was not meaningfully different (SMD, –0.10, –0.28 to 0.09).

The improvements observed in total cholesterol and triglycerides were more pronounced in participants who were vitamin D-deficient at baseline.

The present data indicate that clinicians may consider supplementing regular cholesterol treatments with vitamin D in patients with hypercholesterolaemia and vitamin D deficiency.

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Most Read Articles
Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Yesterday
Cryptococcosis is more common in nonhuman immunodeficiency virus (HIV) nontransplant (NHNT) patients, and this population tends to have more localized pulmonary cryptococcosis and significantly higher 90-day mortality, reports a study.
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