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Vitamin D supplementation helps reduce atopic dermatitis severity

01 Dec 2018

Increasing serum 25-hydroxyvitamin D (25(OH)D) levels to >20 ng/ml on top of standard therapy may yield reductions in severity of atopic dermatitis, a study has found.

A total of 65 atopic dermatitis patients were randomized to receive either vitamin D3 at 5,000 IU/day (n=33) or placebo (n=32) plus baseline therapy (topical steroid, soap substitute and emollient) for 3 months. Disease severity was assessed according to Hanifin-Rajka criteria and the severity scale (SCORAD).

Analysis included 58 patients. Serum 25(OH)D levels at the end of the intervention were significantly higher in the treated vs placebo group (p<0.001).

At week 12, patients with higher serum levels of 25(OH)D (≥20 ng/ml), regardless of whether they received supplementation, had a lower SCORAD relative to those with lower levels (<20 ng/ml; p<0.001). Furthermore, the majority (n=9; 80 percent) of patients with lower vitamin D levels had moderate–severe atopic dermatitis despite standard treatment.

Increased vitamin D levels (≥20 ng/ml) resulting from supplementation was strongly associated with remission of atopic dermatitis (p=0.03). This association persisted in patients with serum levels of ≥20 and ≥30 ng/ml.

The present data suggest that vitamin D3 be considered as a relevant adjuvant in the treatment of atopic dermatitis, researchers said. The dose administered in the cohort proved to be safe and effective for increasing 25(OH)D to levels of sufficiency in 3 months.

Additional investigation is needed to establish the cost-benefit ratio of measuring serum 25(OH)D in patients with AD, particularly those with poor response to standard treatment or with relapses, researchers added.

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Most Read Articles
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.