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Stephen Padilla, 6 days ago
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Vitamin D supplementation helps reduce atopic dermatitis severity

01 Dec 2018

Increasing serum 25-hydroxyvitamin D (25(OH)D) levels to >20 ng/ml on top of standard therapy may yield reductions in severity of atopic dermatitis, a study has found.

A total of 65 atopic dermatitis patients were randomized to receive either vitamin D3 at 5,000 IU/day (n=33) or placebo (n=32) plus baseline therapy (topical steroid, soap substitute and emollient) for 3 months. Disease severity was assessed according to Hanifin-Rajka criteria and the severity scale (SCORAD).

Analysis included 58 patients. Serum 25(OH)D levels at the end of the intervention were significantly higher in the treated vs placebo group (p<0.001).

At week 12, patients with higher serum levels of 25(OH)D (≥20 ng/ml), regardless of whether they received supplementation, had a lower SCORAD relative to those with lower levels (<20 ng/ml; p<0.001). Furthermore, the majority (n=9; 80 percent) of patients with lower vitamin D levels had moderate–severe atopic dermatitis despite standard treatment.

Increased vitamin D levels (≥20 ng/ml) resulting from supplementation was strongly associated with remission of atopic dermatitis (p=0.03). This association persisted in patients with serum levels of ≥20 and ≥30 ng/ml.

The present data suggest that vitamin D3 be considered as a relevant adjuvant in the treatment of atopic dermatitis, researchers said. The dose administered in the cohort proved to be safe and effective for increasing 25(OH)D to levels of sufficiency in 3 months.

Additional investigation is needed to establish the cost-benefit ratio of measuring serum 25(OH)D in patients with AD, particularly those with poor response to standard treatment or with relapses, researchers added.

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Most Read Articles
Stephen Padilla, 6 days ago
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.