Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.

Vitamin D supplementation does not improve semen quality in infertile men

12 Mar 2018
The difference of expectations of infertility treatments between a man and a woman can create difficulty for couples to know when they should stop trying.

There is no improvement in semen quality among vitamin D-insufficient infertile men taking high-dose vitamin D supplementation, a recent study has found.

Men in the treatment group had significantly higher serum 25-hydroxyvitamin-D (25OHD) levels and 1,25-dihydroxyvitamin D3 than those in the placebo group.

No association existed between vitamin D supplementation and changes in semen parameters, but spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group (7.3 percent vs 2.4 percent; Δ5.0 percent (–0.6 to 10.5 percent).

A subgroup of oligozoospermic men receiving vitamin D treatment had a higher likelihood for a live birth compared with those on placebo (35.6 percent vs 18.3 percent; Δ17.3 percent; 1.6–32.9 percent). In addition, vitamin D-deficient men who were randomized to receive high-dose vitamin D supplementation had higher serum inhibin B levels (193 vs 143 pg/mL; Δ49 pg/mL; 8–91 pg/mL). However, increase in sperm concentration was not significantly higher than in the placebo group (p=0.07).

“The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D–deficient men may be of clinical importance and warrant verification by others,” the authors said.

In this single-centre, triple-blinded, randomized clinical trial, 1,427 infertile men were screened to include 330. A total of 1,007 men were excluded, while 95 declined to participate. The active group received cholecalciferol 300,000 IU initially, then 1,400 IU cholecalciferol and 500 mg of calcium daily for 150 days. The other group was given placebo.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.