Vitamin D supplementation does not improve semen quality in infertile men
There is no improvement in semen quality among vitamin D-insufficient infertile men taking high-dose vitamin D supplementation, a recent study has found.
Men in the treatment group had significantly higher serum 25-hydroxyvitamin-D (25OHD) levels and 1,25-dihydroxyvitamin D3 than those in the placebo group.
No association existed between vitamin D supplementation and changes in semen parameters, but spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group (7.3 percent vs 2.4 percent; Δ5.0 percent (–0.6 to 10.5 percent).
A subgroup of oligozoospermic men receiving vitamin D treatment had a higher likelihood for a live birth compared with those on placebo (35.6 percent vs 18.3 percent; Δ17.3 percent; 1.6–32.9 percent). In addition, vitamin D-deficient men who were randomized to receive high-dose vitamin D supplementation had higher serum inhibin B levels (193 vs 143 pg/mL; Δ49 pg/mL; 8–91 pg/mL). However, increase in sperm concentration was not significantly higher than in the placebo group (p=0.07).
“The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D–deficient men may be of clinical importance and warrant verification by others,” the authors said.
In this single-centre, triple-blinded, randomized clinical trial, 1,427 infertile men were screened to include 330. A total of 1,007 men were excluded, while 95 declined to participate. The active group received cholecalciferol 300,000 IU initially, then 1,400 IU cholecalciferol and 500 mg of calcium daily for 150 days. The other group was given placebo.