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Vitamin D supplementation does not improve semen quality in infertile men

12 Mar 2018
The difference of expectations of infertility treatments between a man and a woman can create difficulty for couples to know when they should stop trying.

There is no improvement in semen quality among vitamin D-insufficient infertile men taking high-dose vitamin D supplementation, a recent study has found.

Men in the treatment group had significantly higher serum 25-hydroxyvitamin-D (25OHD) levels and 1,25-dihydroxyvitamin D3 than those in the placebo group.

No association existed between vitamin D supplementation and changes in semen parameters, but spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group (7.3 percent vs 2.4 percent; Δ5.0 percent (–0.6 to 10.5 percent).

A subgroup of oligozoospermic men receiving vitamin D treatment had a higher likelihood for a live birth compared with those on placebo (35.6 percent vs 18.3 percent; Δ17.3 percent; 1.6–32.9 percent). In addition, vitamin D-deficient men who were randomized to receive high-dose vitamin D supplementation had higher serum inhibin B levels (193 vs 143 pg/mL; Δ49 pg/mL; 8–91 pg/mL). However, increase in sperm concentration was not significantly higher than in the placebo group (p=0.07).

“The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D–deficient men may be of clinical importance and warrant verification by others,” the authors said.

In this single-centre, triple-blinded, randomized clinical trial, 1,427 infertile men were screened to include 330. A total of 1,007 men were excluded, while 95 declined to participate. The active group received cholecalciferol 300,000 IU initially, then 1,400 IU cholecalciferol and 500 mg of calcium daily for 150 days. The other group was given placebo.

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Most Read Articles
4 days ago
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
6 days ago
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
6 days ago
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
Patients with chronic kidney disease appear to be at greater risk of developing type 2 diabetes mellitus (T2DM) compared with the general population, with predictors including poor baseline glycaemic control and family history of diabetes mellitus, a study has found.