Most Read Articles
Tristan Manalac, 11 Jul 2018
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Vitamin D supplementation does not improve semen quality in infertile men

12 Mar 2018
The difference of expectations of infertility treatments between a man and a woman can create difficulty for couples to know when they should stop trying.

There is no improvement in semen quality among vitamin D-insufficient infertile men taking high-dose vitamin D supplementation, a recent study has found.

Men in the treatment group had significantly higher serum 25-hydroxyvitamin-D (25OHD) levels and 1,25-dihydroxyvitamin D3 than those in the placebo group.

No association existed between vitamin D supplementation and changes in semen parameters, but spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group (7.3 percent vs 2.4 percent; Δ5.0 percent (–0.6 to 10.5 percent).

A subgroup of oligozoospermic men receiving vitamin D treatment had a higher likelihood for a live birth compared with those on placebo (35.6 percent vs 18.3 percent; Δ17.3 percent; 1.6–32.9 percent). In addition, vitamin D-deficient men who were randomized to receive high-dose vitamin D supplementation had higher serum inhibin B levels (193 vs 143 pg/mL; Δ49 pg/mL; 8–91 pg/mL). However, increase in sperm concentration was not significantly higher than in the placebo group (p=0.07).

“The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D–deficient men may be of clinical importance and warrant verification by others,” the authors said.

In this single-centre, triple-blinded, randomized clinical trial, 1,427 infertile men were screened to include 330. A total of 1,007 men were excluded, while 95 declined to participate. The active group received cholecalciferol 300,000 IU initially, then 1,400 IU cholecalciferol and 500 mg of calcium daily for 150 days. The other group was given placebo.

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Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.