Most Read Articles
07 Mar 2018
The use of trabecular bone score (TBS) may be helpful in evaluating osteoporosis in ankylosing spondylitis (AS), as it is associated with the erythrocyte sedimentation rate (ESR) and severity of sacroiliitis in young male patients with AS, suggests a recent study.
Kathlin Ambrose, 12 Jun 2015
An expert consensus has developed evidence-based recommendations, which aims to provide crucial guidance to support family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS).

Vitamin D reduces anti-dsDNA positivity in systemic lupus erythematosus

25 Jul 2017
Vitamin D supplementation decreases positivity to anti-double stranded (ds) DNA in systemic lupus erythematosus (SLE), according to a new meta-analysis.

A meta-analysis of three studies (intervention group, n=233; placebo, n=128) that evaluated the positivity to anti-dsDNA in SLE showed that vitamin D supplementation resulted in a significant drop in anti-dsDNA positivity (risk difference, -0.10; 95 percent CI, -0.18 to -0.03; p=0.005).

After 6 months of vitamin D supplementation, the following fatigue measurements in SLE showed significant improvements: fatigue interfering with social life (p=0.01), fatigue considered a problem (p=0.03), fatigue from medium effort (p=0.02), fatigue easily (p=0.003) and fatigue when performing exercise (p=0.03).

On the other hand, in rheumatoid arthritis (RA), vitamin D did not have significant effects on the visual analogue scale (VAS; mean difference, 2.79; -1.87 to 7.44; p=0.24) or on the disease activity score 28 (DAS-28; mean difference, -0.31; -0.86 to 0.25; p=0.28), according to an analysis of two studies (intervention, n=61; placebo, n=59).

Two other studies (intervention, n=124; placebo, n=128) showed that RA recurrence decreased although insignificantly (mean difference, -0.10; -0.21 to 0.00; p=0.05).

The meta-analysis included seven randomized controlled trials that investigated the effects of vitamin D supplementation on adult participants with immune-mediated rheumatic diseases. Those with exclusively bone metabolism or cardiovascular endpoints were excluded.

The databases of Medline, Embase, Lilacs, CINAHL and Cochrane were accessed for this meta-analysis.

Quality of the studies was measured from the following criteria: query of the study, randomization, blinding, concealment, participant attrition, homogeneity, outcome measures and intention-to-treat analysis. All studies had a high risk of bias for at least one of the aforementioned criteria.

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Most Read Articles
07 Mar 2018
The use of trabecular bone score (TBS) may be helpful in evaluating osteoporosis in ankylosing spondylitis (AS), as it is associated with the erythrocyte sedimentation rate (ESR) and severity of sacroiliitis in young male patients with AS, suggests a recent study.
Kathlin Ambrose, 12 Jun 2015
An expert consensus has developed evidence-based recommendations, which aims to provide crucial guidance to support family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS).