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01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.

Vitamin D levels do not factor in IVF success

31 Oct 2020

Serum levels of vitamin D do not appear to affect in-vitro fertilization (IVF) outcomes such as clinical pregnancy rate (CPR), live birth rate (LBR), and ongoing pregnancy rate (OPR), according to the results of a meta-analysis.

The meta-analysis included 14 studies evaluating the possible association between vitamin D serum levels and IVF outcomes. These studies contributed to a total of 4,382 women. Vitamin D levels were classified into three groups: deficient (<20 ng/mL), insufficient (20−30 ng/mL), and replete (>30 ng/mL).

Pooled data revealed that compared with women who had deficient of insufficient level of vitamin D, those with a replete level had higher CPR (odds ratio [OR], 0.68, 95 percent confidence interval [CI], 0.48–0.98; I2, 57 percent; p=0.04) and LBR/OPR (OR, 0.72, 95 percent CI, 0.53–0.97; I2, 29 percent; p=0.03).

However, the associations disappeared on a sensitivity analysis (CPR: OR, 0.71, 95 percent CI, 0.47−1.08; I2, 61 percent; OPR/LBR: OR, 0.78, 95 percent CI, 0.56−1.08; I2, 61 percent).

Results were not significant for miscarriage.

The findings suggest that vitamin D serum levels assessed before IVF cycles should not be considered as a prognostic factor for IVF success. Nevertheless, additional investigation is warranted to establish the role of vitamin D in reproductive medicine and determine whether the threshold of vitamin D studied in relation to reproductive health is extremely low compared to those used for bone healthcare and whether it differs among different ethnic groups.

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Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.