Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 4 days ago
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.

Vitamin D fortification improves chances of live birth in infertile women

31 Dec 2019

A margarine fortification programme that exposes infertile women to extra vitamin D leads to better odds of live birth, a study has found.

The study included 16,212 women diagnosed with infertility. Researchers used data from the mandatory vitamin D fortification of margarine in Denmark, which was terminated in 1985. The termination served as a cutoff point to divide the study population into the following exposure groups: 1) the vitamin D–exposed group (women who had their primary infertility diagnosis in the fortification period; n=6,313); 2) a washout-period group (women with a primary infertility diagnosis in 1985–1986; n=1,404); 3) a vitamin D–nonexposed group (women diagnosed with primary infertility in 1986–1991; n=8,495).

Chances of a live birth within 12 months after diagnosis were higher in the exposed group (odds ratio [OR], 1.87, 95 percent confidence interval [CI], 1.68–2.08) relative to the nonexposed group. In the washout group, the estimate was somewhat lower compared to that in the exposed group although still better than in the nonexposed group (OR, 1.52, 95 percent CI, 1.27–1.81)

Estimates or overall risk patterns were similar in analyses covering a longer follow-up (15–18 months after infertility diagnosis) and restricted to women with anovulatory infertility. There was a little seasonal variation when calendar period of conception was applied.

The present data support the hypothesis that sufficient vitamin D levels help increase the chances of live birth in infertile women, according to the researchers. Additional studies are warranted to establish the potential biologic mechanisms linking vitamin D to chance of live birth in infertile women, as well as to determine who may benefit from supplementation with vitamin D and what the optimal dose is for those in need of supplementation.

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Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 4 days ago
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.