Most Read Articles
Pearl Toh, 4 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.

Vitamin D fortification improves chances of live birth in infertile women

31 Dec 2019

A margarine fortification programme that exposes infertile women to extra vitamin D leads to better odds of live birth, a study has found.

The study included 16,212 women diagnosed with infertility. Researchers used data from the mandatory vitamin D fortification of margarine in Denmark, which was terminated in 1985. The termination served as a cutoff point to divide the study population into the following exposure groups: 1) the vitamin D–exposed group (women who had their primary infertility diagnosis in the fortification period; n=6,313); 2) a washout-period group (women with a primary infertility diagnosis in 1985–1986; n=1,404); 3) a vitamin D–nonexposed group (women diagnosed with primary infertility in 1986–1991; n=8,495).

Chances of a live birth within 12 months after diagnosis were higher in the exposed group (odds ratio [OR], 1.87, 95 percent confidence interval [CI], 1.68–2.08) relative to the nonexposed group. In the washout group, the estimate was somewhat lower compared to that in the exposed group although still better than in the nonexposed group (OR, 1.52, 95 percent CI, 1.27–1.81)

Estimates or overall risk patterns were similar in analyses covering a longer follow-up (15–18 months after infertility diagnosis) and restricted to women with anovulatory infertility. There was a little seasonal variation when calendar period of conception was applied.

The present data support the hypothesis that sufficient vitamin D levels help increase the chances of live birth in infertile women, according to the researchers. Additional studies are warranted to establish the potential biologic mechanisms linking vitamin D to chance of live birth in infertile women, as well as to determine who may benefit from supplementation with vitamin D and what the optimal dose is for those in need of supplementation.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 4 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.