Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.

Vitamin D deficiency predicts rapid lung function decline in smokers

22 Apr 2021

Smokers with consistently low serum vitamin D level (SVDL) are likely to exhibit accelerated decline in lung function, a study has found.

The study included 1,371 individuals whose serial SVDL and lung function data were analysed using linear mixed models. The analysis was stratified according to smoking status.

Lung function was measured as the forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC ratio. Vitamin D deficiency was defined as SVDLs being consistently below 20 ng/mL at all measurements.

In smokers, the decline rates of mean FEV1 were significantly greater among those with vitamin D deficiency than among those with normal levels (–33.35 mL/year, 95 percent confidence interval [CI], –39.44 to –27.26 vs –15.61 mL/year, 95 percent CI, –27.29 to –4.21; p<0.001) over a mean of 6.29 years of observation.

A similar pattern of decline was observed for FVC in smokers, where the decline occurred more rapidly among those who were vitamin D-deficient (p<0.001).

Meanwhile, the decline rates in FEV1 and FVC did not differ between participants with and without vitamin D deficiency among nonsmokers. The same was true for FEV1/FVC ratio decline rates regardless of the smoking status.

The findings suggest that vitamin D deficiency may be used to identify healthy smokers at high risk for accelerated lung function decline.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.