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Vitamin D deficiency implicated in lumbar disc degeneration, lower back pain in women

13 Mar 2020

Postmenopausal women with vitamin D deficiency are at greater odds of having lumbar disc degeneration (LDD) and low back pain (LBP), with a serum vitamin D concentration of <10 ng/mL being a marker of severe LDD and LBP, as reported in a recent study.

Researchers looked at 232 women (mean age, 65.6 years). They measured serum concentrations of bone turnover markers by electrochemiluminescence assays and evaluated disc degeneration using the Pfirrmann grading system.

The mean serum 25(OH)D concentration of the cohort was 19.38 ng/mL, with 12.9 percent of women having severe vitamin D deficiency (<10 ng/mL) and 12.5 percent having normal status (>30 ng/mL). Relative to other vitamin D status groups, the severely deficient group had higher visual analogue scale (VAS) scores for LBP (p=0.002) and lower bone mineral density T scores (p=0.004).

There was a strong association between lower 25(OH)D concentration (<10 ng/mL) and more severe LDD in the lumbosacral region (L4-S1, L1-S1; p<0.05) but not in the upper lumbar region. Moreover, vitamin D concentration was inversely related to the severity of disc degeneration (L2-L3, L4-S1, L1-S1; p<0.05).

On analysis adjusted for confounding factors, significant factors associated with a higher prevalence of moderate-to-severe pain in postmenopausal women were as follows: smoking, vitamin D deficiency, lack of vitamin D supplementation, high body mass index and low bone mineral density T score (p<0.05).

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Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
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4 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
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