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Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
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Vitamin D deficiency factors in fibroid development

01 May 2021

Women with vitamin D deficiency are at heightened risk of developing asymptomatic uterine fibroids, a study suggests.

The study looked at premenopausal Han Chinese women and enrolled 133 asymptomatic patients with UFs and 80 women without the benign smooth muscle tumours (controls). Age matching yielded 61 pairs.

All age-matched participants had their medical history assessed and vitamin D concentrations measured. They also underwent transvaginal or transabdominal genital ultrasound scan and blood sampling.

Patients had significantly lower vitamin D levels than controls both in the unmatched (12.1 vs 16.8 ng/mL) and matched samples (11.4 vs 17.5 ng/mL). Furthermore, vitamin D levels were lower in younger women (≤40 years) in the patient group than older women in healthy control group (15.1 vs 19.0 ng/mL).

There was no age–vitamin D interactive effect observed in unmatched samples.

Multivariate logistic regression models confirmed that the presence of asymptomatic uterine fibroids correlated with decreased vitamin D concentrations in both unmatched and matched samples. In addition, the optimal threshold vitamin D level for predicting asymptomatic UFs was 14.34 ng/mL.

Some studies report that vitamin D supplementation may prevent the development and growth of uterine fibroids. As such, vitamin D seems to be a promising, safe, and low-cost approach in the prevention or treatment of these benign tumours. Exploring vitamin D preparations as a new generation of antifibroid drugs is said to be an exciting area of research. [Int J Mol Sci 2018;19:2051]

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.