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Vitamin D deficiency, insufficiency tied to peripheral arterial disease

08 Jul 2018

Vitamin D levels are lower in patients with peripheral arterial disease (PAD) compared with controls, and both vitamin D deficiency and insufficiency are significantly associated with PAD, according to the results of a meta-analysis. In addition, lower levels of vitamin D may signify an independent risk factor for PAD and for cardiovascular (CV) events.

The meta-analysis included 10 studies with available data on vitamin D levels in 2,079 patients with PAD and 18,233 non-PAD controls, and six studies on the prevalence of PAD in 23,171 patients with vitamin D deficiency (<20 ng/mL), 48,311 with vitamin D insufficiency (20–30 ng/mL) and 27,910 with normal vitamin D levels (>30 ng/mL).

Patients with PAD, compared with controls, had significantly reduced vitamin D levels (mean difference, –2.24 ng/mL; 95 percent CI, –3.38 to –1.10; p<0.001; I2, 86.5 percent; p<0.001). PAD prevalence was also higher in patients with vitamin D insufficiency (odds ratio [OR], 1.098; 1.010–1.195; p=0.029; I2, 0 percent; p=0.600) and in those with vitamin D deficiency (OR, 1.484; 1.348–1.635; p<0.001; I2, 7.65 percent; p=0.367) vs controls with normal vitamin D levels.

Results were consistent in sensitivity analyses and the analysis of data on the cumulative risk of PAD according to vitamin D levels derived from multivariate analysis.

The authors systematically searched in the PubMed, Web of Sciences, Scopus and Embase databases, and performed a meta-analysis of studies evaluating the association between vitamin D status and PAD.

“Patients with vitamin D deficiency have increased CV morbidity and mortality,” the authors noted.

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Most Read Articles
15 Sep 2018
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
13 Sep 2018
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
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The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.