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Vitamin D deficiency, insufficiency tied to peripheral arterial disease

08 Jul 2018

Vitamin D levels are lower in patients with peripheral arterial disease (PAD) compared with controls, and both vitamin D deficiency and insufficiency are significantly associated with PAD, according to the results of a meta-analysis. In addition, lower levels of vitamin D may signify an independent risk factor for PAD and for cardiovascular (CV) events.

The meta-analysis included 10 studies with available data on vitamin D levels in 2,079 patients with PAD and 18,233 non-PAD controls, and six studies on the prevalence of PAD in 23,171 patients with vitamin D deficiency (<20 ng/mL), 48,311 with vitamin D insufficiency (20–30 ng/mL) and 27,910 with normal vitamin D levels (>30 ng/mL).

Patients with PAD, compared with controls, had significantly reduced vitamin D levels (mean difference, –2.24 ng/mL; 95 percent CI, –3.38 to –1.10; p<0.001; I2, 86.5 percent; p<0.001). PAD prevalence was also higher in patients with vitamin D insufficiency (odds ratio [OR], 1.098; 1.010–1.195; p=0.029; I2, 0 percent; p=0.600) and in those with vitamin D deficiency (OR, 1.484; 1.348–1.635; p<0.001; I2, 7.65 percent; p=0.367) vs controls with normal vitamin D levels.

Results were consistent in sensitivity analyses and the analysis of data on the cumulative risk of PAD according to vitamin D levels derived from multivariate analysis.

The authors systematically searched in the PubMed, Web of Sciences, Scopus and Embase databases, and performed a meta-analysis of studies evaluating the association between vitamin D status and PAD.

“Patients with vitamin D deficiency have increased CV morbidity and mortality,” the authors noted.

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Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 18 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.