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Vitamin D deficiency, insufficiency may increase risk of CV events

17 Jul 2017

Both insufficiency and deficiency in vitamin D are linked to subclinical atherosclerosis, which potentially suggests an elevated cardiovascular (CV) risk, according to a recent study.

Researchers systematically searched PubMed, Web of Science Scopus and Embase databases for studies assessing the impact of vitamin D deficiency on common carotid artery intima-media thickness (CCA-IMT) and prevalence of carotid plaques, which are markers of subclinical atherosclerosis and predictors of CV events.

A total of 21 studies (3,777 vitamin D-deficient patients and 4,792 controls) with data on CCA-IMT and six studies (1,889 vitamin D-deficient patients and 2,883 controls) on the prevalence of carotid plaques met the inclusion criteria.

There was significantly higher CCA-IMT (mean difference [MD], 0.043 mm; 95 percent CI, 0.030 to 0.056; p<0.001) and an increased prevalence of carotid plaques (odds ratio [OR], 2.29; 1.03 to 5.11; p=0.043) with an attributable risk of 35.9 percent among patients with vitamin D deficiency compared with controls.

When selecting for studies specifically including patients with diabetes, those with vitamin D deficiency showed higher prevalence of carotid plaques than controls (OR, 3.27; 1.62 to 6.62; p=0.001). There was a significant difference in CCA-IMT when comparing vitamin D-insufficient patients with controls (MD, 0.011; 0.010 to 0.012; p<0.001).

Results were substantially confirmed by sensitivity analyses, while regression models demonstrated that all of the other clinical and demographic covariates—with the exception of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and the prevalence of hypercholesterolemia—significantly impacted on the difference in CCA-IMT between vitamin D-deficient patients and controls

Patients with vitamin D deficiency have an increased CV morbidity and mortality, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

5 days ago
Oestradiol therapy appears to protect certain types of cognition in the presence of stress, suggests a recent study.
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.