Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
A small cohort study presented at the Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2018 has reported a 5-year diabetic ketoacidosis (DKA) incidence rate of 4.16 percent in pregnant women with type 1 diabetes mellitus (T1DM), with generally good maternal and neonatal outcomes.
24 Apr 2018
A subclinical inflammatory state resulting from increased adiposity and metabolic dysfunction appears to contribute to breast cancer pathogenesis in Asian women, a Taiwan study has found.

Vitamin D deficiency, insufficiency may increase risk of CV events

17 Jul 2017

Both insufficiency and deficiency in vitamin D are linked to subclinical atherosclerosis, which potentially suggests an elevated cardiovascular (CV) risk, according to a recent study.

Researchers systematically searched PubMed, Web of Science Scopus and Embase databases for studies assessing the impact of vitamin D deficiency on common carotid artery intima-media thickness (CCA-IMT) and prevalence of carotid plaques, which are markers of subclinical atherosclerosis and predictors of CV events.

A total of 21 studies (3,777 vitamin D-deficient patients and 4,792 controls) with data on CCA-IMT and six studies (1,889 vitamin D-deficient patients and 2,883 controls) on the prevalence of carotid plaques met the inclusion criteria.

There was significantly higher CCA-IMT (mean difference [MD], 0.043 mm; 95 percent CI, 0.030 to 0.056; p<0.001) and an increased prevalence of carotid plaques (odds ratio [OR], 2.29; 1.03 to 5.11; p=0.043) with an attributable risk of 35.9 percent among patients with vitamin D deficiency compared with controls.

When selecting for studies specifically including patients with diabetes, those with vitamin D deficiency showed higher prevalence of carotid plaques than controls (OR, 3.27; 1.62 to 6.62; p=0.001). There was a significant difference in CCA-IMT when comparing vitamin D-insufficient patients with controls (MD, 0.011; 0.010 to 0.012; p<0.001).

Results were substantially confirmed by sensitivity analyses, while regression models demonstrated that all of the other clinical and demographic covariates—with the exception of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and the prevalence of hypercholesterolemia—significantly impacted on the difference in CCA-IMT between vitamin D-deficient patients and controls

Patients with vitamin D deficiency have an increased CV morbidity and mortality, according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
A small cohort study presented at the Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2018 has reported a 5-year diabetic ketoacidosis (DKA) incidence rate of 4.16 percent in pregnant women with type 1 diabetes mellitus (T1DM), with generally good maternal and neonatal outcomes.
24 Apr 2018
A subclinical inflammatory state resulting from increased adiposity and metabolic dysfunction appears to contribute to breast cancer pathogenesis in Asian women, a Taiwan study has found.