Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.

Vitamin D deficiency, insufficiency may increase risk of CV events

17 Jul 2017

Both insufficiency and deficiency in vitamin D are linked to subclinical atherosclerosis, which potentially suggests an elevated cardiovascular (CV) risk, according to a recent study.

Researchers systematically searched PubMed, Web of Science Scopus and Embase databases for studies assessing the impact of vitamin D deficiency on common carotid artery intima-media thickness (CCA-IMT) and prevalence of carotid plaques, which are markers of subclinical atherosclerosis and predictors of CV events.

A total of 21 studies (3,777 vitamin D-deficient patients and 4,792 controls) with data on CCA-IMT and six studies (1,889 vitamin D-deficient patients and 2,883 controls) on the prevalence of carotid plaques met the inclusion criteria.

There was significantly higher CCA-IMT (mean difference [MD], 0.043 mm; 95 percent CI, 0.030 to 0.056; p<0.001) and an increased prevalence of carotid plaques (odds ratio [OR], 2.29; 1.03 to 5.11; p=0.043) with an attributable risk of 35.9 percent among patients with vitamin D deficiency compared with controls.

When selecting for studies specifically including patients with diabetes, those with vitamin D deficiency showed higher prevalence of carotid plaques than controls (OR, 3.27; 1.62 to 6.62; p=0.001). There was a significant difference in CCA-IMT when comparing vitamin D-insufficient patients with controls (MD, 0.011; 0.010 to 0.012; p<0.001).

Results were substantially confirmed by sensitivity analyses, while regression models demonstrated that all of the other clinical and demographic covariates—with the exception of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and the prevalence of hypercholesterolemia—significantly impacted on the difference in CCA-IMT between vitamin D-deficient patients and controls

Patients with vitamin D deficiency have an increased CV morbidity and mortality, according to researchers.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.