Most Read Articles
Jairia Dela Cruz, 09 Aug 2019
Uric acid-lowering therapy for gout also confers benefits for hyperlipidaemia, with febuxostat delivering greater reductions in cholesterol and triglyceride concentrations in the blood as compared with allopurinol and benzbromarone, according to a recent study.
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

31 Jul 2019
New drug applications approved by US FDA as of 16 - 31 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
12 Aug 2019
Chronic exposure to higher cortisol levels among patients with Turner syndrome (TS) is linked to short stature and greater total cholesterol levels, according to a study. Cortisol exposure also contributes to an increase in cardiovascular disease risk.

Vitamin D, oestrogen protect against metabolic syndrome after menopause

17 Jul 2019

Deficiencies in vitamin D and oestrogen contribute to additive increases in the risk of metabolic syndrome in postmenopausal women, a recent study has found.

The cross-sectional study included 616 postmenopausal women aged 49-86 years. None of them were taking oestrogen and vitamin D/calcium supplements. Researchers measured serum oestradiol (E2) and 25(OH)D for each participant in relation to the risk of metabolic syndrome, which was defined according to the 2006 International Diabetes Federation standard.

Results showed a positive correlation between 25(OH)D and E2. Higher 25(OH)D concentration was associated with a favourable lipid profile, blood pressure and glucose level. On the other hand, higher E2 concentration was associated with low levels of cholesterol, triglycerides and blood pressure.

Women with vitamin D deficiency were twice as likely as those with sufficient vitamin D levels to have metabolic syndrome (odds ratio [OR], 2.19, 95 percent CI, 1.19–4.01; p-trend=0.009). This association remained significant despite controlling for E2 levels.

On further analysis stratifying by vitamin D status, low E2 concentration augmented the risk of metabolic syndrome in women with vitamin D deficiency (lowest vs highest tertile of E2: OR, 3.49, 1.45–8.05).

The present data suggest that vitamin D and E2 deficiencies exert a potential synergistic effect on the risk of metabolic syndrome in postmenopausal women, the researchers said.

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Most Read Articles
Jairia Dela Cruz, 09 Aug 2019
Uric acid-lowering therapy for gout also confers benefits for hyperlipidaemia, with febuxostat delivering greater reductions in cholesterol and triglyceride concentrations in the blood as compared with allopurinol and benzbromarone, according to a recent study.
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

31 Jul 2019
New drug applications approved by US FDA as of 16 - 31 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
12 Aug 2019
Chronic exposure to higher cortisol levels among patients with Turner syndrome (TS) is linked to short stature and greater total cholesterol levels, according to a study. Cortisol exposure also contributes to an increase in cardiovascular disease risk.