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Vitamin D, fish oil supplements beneficial to children with nocturnal enuresis

27 Feb 2018

Supplementation with vitamin D and omega-3 affords reductions in the number of wet nights among 7–15-year-old patients with nocturnal enuresis, a recent study has shown.

The 2-month study randomly assigned 180 paediatric patients with nocturnal enuresis to the following treatment groups: vitamin D (1,000 IU/day), group A; omega-3 (1,000 mg/day), group B; and both omega-3 (1,000 mg/day) and vitamin D (1,000 IU/day), group C; placebo, group D.

Researchers collected demographic information, anthropometric measures, and fasting blood and urine samples. Serum 25(OH)D and urine prostaglandin E2 were measured before and after intervention.

There were no significant differences with respect to demographic and anthropometric measures at baseline. Enuresis was cured in 44.4 percent of patients in group A, 28.2 percent in group B and 45 percent in group C (p=0.03).

Supplementation led to an increase in serum 25(OH)D in group A, but not to a decrease in urine prostaglandin E2.

Furthermore, while supplementation with either vitamin D or omega-3 proved to be effective, the combination of both supplements did not increase the effect of each intervention solely.

Findings of the present study suggest that vitamin D and omega-3 may have therapeutic potential for nocturnal enuresis in children, although the mechanism of the supplements’ effect on wet nights in enuretic children remains unclear, researchers said.

More work is needed to determine the dosage of vitamin D and omega-3 supplements that could be more effective, and future studies should follow children to assess the rate of relapse following withdrawal.

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