Most Read Articles
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.

Elaine Soliven, 24 Feb 2020
Administering intravenous propranolol hydrochloride does not reduce the duration of labour induction for nulliparous women who undergo vaginal delivery, according to a study presented at SMFM 2020.

Vismodegib holds therapeutic potential in advanced basal cell carcinoma

10 Jan 2020

The Hedgehog pathway inhibitor vismodegib appears to be effective in the treatment of locally advanced periocular basal cell carcinoma (BCC), with adverse events (AEs) that are mostly manageable, as reported in a recent study.

The researchers reviewed the medical records of 21 patients (median age, 76 years; 76.2 percent male) with locally advanced and metastatic orbital (n=15) or periocular (n=6) BCC treated with vismodegib. Treatment went on for a median of 9 months.

Follow-up duration was 26 months overall and 17 months after cessation of treatment. Complete response was seen in 10 patients and partial response in another 10 patients, whereas disease remained stable in the remaining patient. Among the complete responders, five sustained a complete response at 16 months and three who stopped treatment experienced recurrence 8 months later.

Most treatment-related adverse reactions were low grade (grade 1 or 2). Frequently reported grade 1 or 2 complications were muscle spasm (76 percent), dysgeusia (57 percent), alopaecia (47 percent), weight loss (47 percent) and reduced appetite (19 percent). Hepatoxicity was the only documented high-grade (grade 3 or 4) adverse event (10 percent).

Treatment was withdrawn in eight patients due to side effects. There were five deaths overall, most of which were deemed unrelated to vismodegib therapy, except for one patient who died from potentially treatment-related sepsis (grade 5 adverse event).

The present data show that long periods of complete tumour regression can be achieved in some patients even after discontinuation of the medication, according to the researchers. However, the optimal treatment protocol and duration have yet to be established, highlighting a need for more prospective multicenter trials.

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Most Read Articles
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.

Elaine Soliven, 24 Feb 2020
Administering intravenous propranolol hydrochloride does not reduce the duration of labour induction for nulliparous women who undergo vaginal delivery, according to a study presented at SMFM 2020.