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Visceral, subcutaneous adipose tissue predicts adverse outcomes in ARDS

09 Mar 2019
73% of workers aged above 40 were also found to be overweight or obese.

The ratio between visceral (VAT) and subcutaneous (SAT) adipose tissue (VAT/SAT) appears to increase the risk of adverse outcomes in patients with acute respiratory distress syndrome (ARDS), a recent study has shown.

Researchers retrospectively analysed 169 ARDS patients, of whom 106 had VAT/SAT <3.22 (mean age 63.82±22.76 years; 53 percent male; mean VAT/SAT, 2.34±0.54) while the remaining 63 had VAT/SAT >3.22 (mean age 64.98±17.46 years; 84 percent male; mean VAT/SAT, 4.74±1.42).

Mortality was significantly elevated in participants with higher VAT/SAT (22 percent vs 44 percent; p<0.01), an effect that remained significant even after adjusting for age, gender, smoking and other confounders (adjusted odds ratio, 0.725; 95 percent CI, 0.544–0.966; p=0.028).

A similar effect was observed for length of stay in the intensive care unit. Those with lower SAT (26.16 vs 15.83 days; p=0.031) and VAT (25.16 vs 14.19 days; p=0.007) tended to have longer stays, though no significant difference was observed when VAT/SAT was considered.

In contrast, the number of days requiring mechanical ventilation was comparable in those with low vs high VAT/SAT (4.38 vs 4.11 days; p=0.765). The same was true when groups were defined according to VAT alone, but significant differences were obtained when participants were categorized according to SAT (3.36 vs 5.00 days; p<0.001).

“More studies of a larger sample size are needed, especially prospective ones designed to explore the role of VAT/SAT and SAT in different classifications of ARDS patients,” said researchers.

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Most Read Articles
Rachel Soon, 2 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

6 days ago
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
Yesterday
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 4 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.