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Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

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Visceral, subcutaneous adipose tissue predicts adverse outcomes in ARDS

09 Mar 2019
73% of workers aged above 40 were also found to be overweight or obese.

The ratio between visceral (VAT) and subcutaneous (SAT) adipose tissue (VAT/SAT) appears to increase the risk of adverse outcomes in patients with acute respiratory distress syndrome (ARDS), a recent study has shown.

Researchers retrospectively analysed 169 ARDS patients, of whom 106 had VAT/SAT <3.22 (mean age 63.82±22.76 years; 53 percent male; mean VAT/SAT, 2.34±0.54) while the remaining 63 had VAT/SAT >3.22 (mean age 64.98±17.46 years; 84 percent male; mean VAT/SAT, 4.74±1.42).

Mortality was significantly elevated in participants with higher VAT/SAT (22 percent vs 44 percent; p<0.01), an effect that remained significant even after adjusting for age, gender, smoking and other confounders (adjusted odds ratio, 0.725; 95 percent CI, 0.544–0.966; p=0.028).

A similar effect was observed for length of stay in the intensive care unit. Those with lower SAT (26.16 vs 15.83 days; p=0.031) and VAT (25.16 vs 14.19 days; p=0.007) tended to have longer stays, though no significant difference was observed when VAT/SAT was considered.

In contrast, the number of days requiring mechanical ventilation was comparable in those with low vs high VAT/SAT (4.38 vs 4.11 days; p=0.765). The same was true when groups were defined according to VAT alone, but significant differences were obtained when participants were categorized according to SAT (3.36 vs 5.00 days; p<0.001).

“More studies of a larger sample size are needed, especially prospective ones designed to explore the role of VAT/SAT and SAT in different classifications of ARDS patients,” said researchers.

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Most Read Articles
5 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

3 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
5 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
3 days ago
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.