Visceral, subcutaneous adipose tissue predicts adverse outcomes in ARDS
The ratio between visceral (VAT) and subcutaneous (SAT) adipose tissue (VAT/SAT) appears to increase the risk of adverse outcomes in patients with acute respiratory distress syndrome (ARDS), a recent study has shown.
Researchers retrospectively analysed 169 ARDS patients, of whom 106 had VAT/SAT <3.22 (mean age 63.82±22.76 years; 53 percent male; mean VAT/SAT, 2.34±0.54) while the remaining 63 had VAT/SAT >3.22 (mean age 64.98±17.46 years; 84 percent male; mean VAT/SAT, 4.74±1.42).
Mortality was significantly elevated in participants with higher VAT/SAT (22 percent vs 44 percent; p<0.01), an effect that remained significant even after adjusting for age, gender, smoking and other confounders (adjusted odds ratio, 0.725; 95 percent CI, 0.544–0.966; p=0.028).
A similar effect was observed for length of stay in the intensive care unit. Those with lower SAT (26.16 vs 15.83 days; p=0.031) and VAT (25.16 vs 14.19 days; p=0.007) tended to have longer stays, though no significant difference was observed when VAT/SAT was considered.
In contrast, the number of days requiring mechanical ventilation was comparable in those with low vs high VAT/SAT (4.38 vs 4.11 days; p=0.765). The same was true when groups were defined according to VAT alone, but significant differences were obtained when participants were categorized according to SAT (3.36 vs 5.00 days; p<0.001).
“More studies of a larger sample size are needed, especially prospective ones designed to explore the role of VAT/SAT and SAT in different classifications of ARDS patients,” said researchers.