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Pearl Toh, 5 days ago
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Vildagliptin, glibenclamide exert neutral effect on endothelial function, arterial stiffness

07 Jan 2019

Treatment with either vildagliptin or glibenclamide does not alter both the endothelial function and arterial stiffness in diabetic and hypertensive patients without cardiovascular disease, a study has shown.

The study randomized 50 patients (mean age 59 years; 64 percent female) with type 2 diabetes mellitus (T2DM) and hypertension, but without cardiovascular disease, to receive either vildagliptin (n=25) or glibenclamide (n=25) for 12 weeks in addition to metformin.

All patients underwent 24-hour noninvasive ambulatory blood pressure monitoring. Additionally, researchers evaluated endothelial function using peripheral artery tonometry (Endo-PAT 2000), which facilitated calculation of the reactive hyperaemia index (RHI), and assessed arterial stiffness using the augmentation index corrected for 75 bpm (AIx75), pulse wave velocity (PWV) and central systolic blood pressure (cSBP).

The primary outcome of RHI after 12 weeks of treatment did not change from baseline in both vildagliptin (from 2.35 to 2.24) and glibenclamide (from 2.36 to 2.34) groups. Furthermore, there were no between-group differences observed in AIx75, cSBP and PWV.

RHI did not correlate with glycaemic control, hypertension, T2DM duration, BP and arterial stiffness in either group. On the other hand, PWV was associated with age, central pulse pressure and office blood pressure.

There were no reports of serious adverse events, and the hypoglycaemic events that occurred in two patients who received glibenclamide group were not significant. One patient in the vildagliptin group discontinued treatment prematurely (7 weeks) and had to initiate insulin treatment due to poor glycaemic control.

More studies are needed to confirm differences between vildagliptin and glibenclamide regarding vascular function, researchers said.

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Most Read Articles
Pearl Toh, 5 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Stephen Padilla, 06 Feb 2019
Alirocumab has prevented nonfatal cardiovascular events and deaths, the total of which is twice the number of first events prevented among patients with acute coronary syndrome (ACS) over a median follow-up of 2.8 years, according to results of the ODYSSEY OUTCOMES* trial. In addition, a robust association is seen between the risks of nonfatal and fatal events during the study.
14 Sep 2017
Rifaximin appears to confer increased survival benefit in hepatic encephalopathy patients without hepatocellular carcinoma (HCC), in addition to reducing the risks of spontaneous bacterial peritonitis, variceal bleeding and recurrent hepatic encephalopathy, according to a study.
13 Dec 2018
It appears that biguanides and statins have inhibitory effect on neuroendocrine tumour (NET)-cell aggressiveness, a recent study has shown.